Anti-androgenic activities of Ganoderma lucidum

被引：82

作者：

Fujita, R

Liu, J

Shimizu, K

Konishi, F

Noda, K

Kumamoto, S

Ueda, C

Tajiri, H

Kaneko, S

Suimi, Y

Kondo, R ^{[1
]}

机构：

[1] Kyushu Univ, Fac Agr, Dept Forest & Forest Prod Sci, Fukuoka 8128581, Japan

[2] Chlorella Ind Co Ltd, Res Labs, Fukuoka 8330056, Japan

[3] Yamaya Conmunicat Co Ltd, Fukuoka 8130061, Japan

[4] Fukuoka Prefecture Forest Res & Extens Ctr, Fukuoka 8390827, Japan

[5] Bisoken & Co Ltd, Oita 8710011, Japan

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2005年 / 102卷 / 01期

关键词：

5; alpha-reductase; Ganoderma lucidum; Ganodermataceae; anti-androgen activities; benign prostatic hyperplasia (BPH);

D O I：

10.1016/j.jep.2005.05.041

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The inhibitory effects of methanol extracts of 19 edible and medicinal mushrooms on 5 alpha-reductase activity were examined. The extract of Ganoderma lucidum Fr. Krast (Ganodermataceae) showed the strongest 5 alpha-reductase inhibitory activity. The treatment of the fruit body of Ganoderma lucidum or the extract prepared from it significantly inhibited the testosterone-induced growth of the ventral prostate in castrated rats. These results showed that Ganoderma lucidum might be a useful ingredient for the treatment of benign prostatic hyperplasia (BPH). (C) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：107 / 112

页数：6

共 27 条

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