Anti-androgenic activities of Ganoderma lucidum

被引：82
作者：
Fujita, R
Liu, J
Shimizu, K
Konishi, F
Noda, K
Kumamoto, S
Ueda, C
Tajiri, H
Kaneko, S
Suimi, Y
Kondo, R [1 ]
机构：
[1] Kyushu Univ, Fac Agr, Dept Forest & Forest Prod Sci, Fukuoka 8128581, Japan
[2] Chlorella Ind Co Ltd, Res Labs, Fukuoka 8330056, Japan
[3] Yamaya Conmunicat Co Ltd, Fukuoka 8130061, Japan
[4] Fukuoka Prefecture Forest Res & Extens Ctr, Fukuoka 8390827, Japan
[5] Bisoken & Co Ltd, Oita 8710011, Japan
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 2005年 / 102卷 / 01期
关键词：
5; alpha-reductase; Ganoderma lucidum; Ganodermataceae; anti-androgen activities; benign prostatic hyperplasia (BPH);
D O I：
10.1016/j.jep.2005.05.041
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The inhibitory effects of methanol extracts of 19 edible and medicinal mushrooms on 5 alpha-reductase activity were examined. The extract of Ganoderma lucidum Fr. Krast (Ganodermataceae) showed the strongest 5 alpha-reductase inhibitory activity. The treatment of the fruit body of Ganoderma lucidum or the extract prepared from it significantly inhibited the testosterone-induced growth of the ventral prostate in castrated rats. These results showed that Ganoderma lucidum might be a useful ingredient for the treatment of benign prostatic hyperplasia (BPH). (C) 2005 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：107 / 112
页数：6
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