uORF Shuffling Fine-Tunes Gene Expression at a Deep Level of the Process

被引：19

作者：

Kurihara, Yukio ^{[1
]}

机构：

[1] RIKEN, Synthet Genom Res Grp, Ctr Sustainable Resource Sci, Tsurumi Ku, 1-7-22 Suehirocho, Yokohama, Kanagawa 2300045, Japan

来源：

PLANTS-BASEL | 2020年 / 9卷 / 05期

关键词：

uORF; translation; ribosome; NMD; OPEN READING FRAMES; MESSENGER-RNA; TRANSLATION REGULATION; STOP CODON; RIBOSOME; ARABIDOPSIS; IDENTIFICATION; GENOME; RESISTANCE; SEQUENCES;

D O I：

10.3390/plants9050608

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Upstream open reading frames (uORFs) are present in the 5' leader sequences (or 5' untranslated regions) upstream of the protein-coding main ORFs (mORFs) in eukaryotic polycistronic mRNA. It is well known that a uORF negatively affects translation of the mORF. Emerging ribosome profiling approaches have revealed that uORFs themselves, as well as downstream mORFs, can be translated. However, it has also been revealed that plants can fine-tune gene expression by modulating uORF-mediated regulation in some situations. This article reviews several proposed mechanisms that enable genes to escape from uORF-mediated negative regulation and gives insight into the application of uORF-mediated regulation for precisely controlling gene expression.

引用

页数：8

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