Developments in hollow fibre-based, liquid-phase microextraction

被引：465
作者：
Rasmussen, KE [1 ]
Pedersen-Biergaard, S [1 ]
机构：
[1] Univ Oslo, Sch Pharm, N-0316 Oslo, Norway
来源：
TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2004年 / 23卷 / 01期
关键词：
drug analysis; environmental analysis; extraction techniques; hollow fibres; liquid-phase microextraction;
D O I：
10.1016/S0165-9936(04)00105-0
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The demand for automation in analytical liquid-liquid extraction (LLE) combined with organic solvent reduction or elimination has led to the recent development of liquid-phase microextraction (LPME) based on disposable hollow fibres. In this concept, analytes of interest are extracted from aqueous samples, through a thin layer of organic solvent immobilized within the pores of a porous hollow fibre, and into an acceptor solution inside the lumen of the hollow fibre. Subsequently, the acceptor solution is directly subjected to a final analysis by capillary gas chromatography (CGC), high-performance liquid chromatography (HPLC), capillary electrophoresis (CE), or mass spectrometry (MS) without any further effort. Hollow fibre-based LPME may provide high analyte pre-concentration and excellent sample clean-up, and it has a broad application potential within areas such as drug analysis and environmental monitoring. This review focuses on basic extraction principles, technical set-up, recovery, enrichment, extraction speed, selectivity, applications, and future trends in hollow fibre-based LPME. (C) 2003 Elsevier Ltd. All rights reserved.
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页码：1 / 10
页数：10
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