Diacid linkers that promote parallel β-sheet secondary structure in water

被引：27

作者：

Freire, Felix ^{[1
]}

Fisk, John D. ^{[1
]}

Peoples, Aaron J. ^{[1
]}

Ivancic, Monika ^{[1
]}

Guzei, Ilia A. ^{[1
]}

Gellman, Samuel H. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 25期

关键词：

D O I：

10.1021/ja802042c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the development of diacid units that promote formation of a two-stranded parallel beta-sheet secondary structure between peptide segments attached via their N-termini. These linker units are formed by attaching glycine to one carboxyl group of cis-1,2-cyclohexanedicarboxylic acid (CHDA). Parallel sheet formation in water is observed when L-residue strands are attached to the CHDA-Gly unit with either of the two absolute configurations.

引用

页码：7839 / +

页数：4

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