Nonpharmacologic Management of Hepatic Encephalopathy: An Update

被引：5
作者：
Weir, Vanessa [1 ]
Reddy, K. Rajender [2 ]
机构：
[1] Univ Penn, Perelman Ctr Adv Med, Dept Med, Div Gastroenterol & Hepatol,HUP, 7 South Pavil,3400 Civ Ctr Blvd, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Med, Div Gastroenterol & Hepatol, HUP, 2 Dulles,3400 Spruce St, Philadelphia, PA 19104 USA
来源：
CLINICS IN LIVER DISEASE | 2020年 / 24卷 / 02期
关键词：
Hepatic encephalopathy; Nonpharmacologic; Probiotics; Fecal microbiota transplant; Nutrition; Prebiotics; Gut microbiome; Branched-chain amino acids; CHAIN AMINO-ACIDS; EXTRACORPOREAL ALBUMIN DIALYSIS; ADSORBENT RECIRCULATING SYSTEM; CHRONIC LIVER-FAILURE; HUMAN GUT MICROBIOME; CIRRHOTIC-PATIENTS; BACTERIAL TRANSLOCATION; NITROGEN-METABOLISM; FECAL MICROBIOTA; PROTEIN-DIET;
D O I：
10.1016/j.cld.2020.01.003
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Research increasingly shows that the gut-liver-brain axis is a crucial component in the pathophysiology of hepatic encephalopathy (HE). Due to the limitations of current standard-of-care medications, non-pharmacological treatments that target gut dysbiosis, including probiotics, nutritional management, and fecal microbiota transplants, are being considered as alternative and adjunct therapies. Meta-analyses note that probiotics could offer benefits in HE treatment, but have not shown superiority over lactulose. Emerging literature suggests that fecal microbiota transplants could offer a novel strategy to treat gut dysbiosis and favorably impact HE. Finally, liver support devices and liver transplantation could offer a last-resort treatment option for persistent HE.
引用
收藏
页码：243 / +
页数：21
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