Track structures, DNA targets and radiation effects in the biophysical Monte Carlo simulation code PARTRAC

被引：315

作者：

Friedland, Werner ^{[1
]}

Dingfelder, Michael ^{[2
]}

Kundrat, Pavel ^{[1
]}

Jacob, Peter ^{[1
]}

机构：

[1] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Radiat Protect, D-85764 Neuherberg, Germany

[2] E Carolina Univ, Dept Phys, Greenville, NC 27858 USA

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2011年 / 711卷 / 1-2期

基金：

美国国家航空航天局;

关键词：

Modelling; Track structure; Multi-scale; DNA damage; DNA repair; DOUBLE-STRAND BREAKS; FRAGMENT-SIZE DISTRIBUTIONS; SMALL CYLINDRICAL TARGETS; NORMAL HUMAN FIBROBLASTS; HUMAN SKIN FIBROBLASTS; LINEAR-ENERGY-TRANSFER; HEAT-LABILE SITES; ULTRASOFT X-RAYS; LIQUID WATER; IONIZING-RADIATION;

D O I：

10.1016/j.mrfmmm.2011.01.003

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

This review describes the PARTRAC suite of comprehensive Monte Carlo simulation tools for calculations of track structures of a variety of ionizing radiation qualities and their biological effects. A multi-scale target model characterizes essential structures of the whole genomic DNA within human fibroblasts and lymphocytes in atomic resolution. Calculation methods and essential results are recapitulated regarding the physical, physico-chemical and chemical stage of track structure development of radiation damage induction. Recent model extension towards DNA repair processes extends the time dimension by about 12 orders of magnitude and paves the way for superior predictions of radiation risks. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：28 / 40

页数：13

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