Solid Dispersion of Resveratrol Supported on Magnesium DiHydroxide (Resv@MDH) Microparticles Improves Oral Bioavailability

被引：36

作者：

Spogli, Roberto ^{[1
]}

Bastianini, Maria ^{[1
]}

Ragonese, Francesco ^{[2
,3
]}

Iannitti, Rossana Giulietta ^{[4
]}

Monarca, Lorenzo ^{[2
]}

Bastioli, Federica ^{[2
]}

Nakashidze, Irina ^{[5
]}

Brecchia, Gabriele ^{[6
]}

Menchetti, Laura ^{[6
]}

Codini, Michela ^{[7
]}

Arcuri, Cataldo ^{[3
]}

Mancinelli, Loretta ^{[2
]}

Fioretti, Bernard ^{[2
]}

机构：

[1] Univ Perugia, Prolabin & Tefarm, Spin Off Un, Via Acciaio 9, I-06134 Perugia, Italy

[2] Univ Perugia, Dept Chem Biol & Biotechnol, Via Elce Sotto 8, I-06123 Perugia, Italy

[3] Univ Perugia, Perugia Med Sch, Dept Expt Med, Piazza Lucio Severi 1, I-06132 Perugia, Italy

[4] S&R Farmaceut SpA Bastia Umbra, I-08063 Perugia, Italy

[5] Batumi Shota Rustaveli State Univ, Fac Nat Sci & Hlth Care, Dept Biol, Batumi 6010, Georgia

[6] Univ Perugia, Dept Vet Sci, Via San Costanzo 4, I-06126 Perugia, Italy

[7] Univ Perugia, Dept Pharmaceut Sci, Via A Fabretti 48, I-06123 Perugia, Italy

来源：

NUTRIENTS | 2018年 / 10卷 / 12期

关键词：

resveratrol; magnesium dihydroxide; solubility; bioavailability; dissolution rate; microparticles; TRANS-RESVERATROL; CLASSIFICATION; DISSOLUTION; SOLUBILITY; METABOLISM; ABSORPTION; DELIVERY; PROFILE; SYSTEM; IMPACT;

D O I：

10.3390/nu10121925

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Resveratrol, because of its low solubility in water and its high membrane permeability, is collocated in the second class of the biopharmaceutical classification system, with limited bioavailability due to its dissolution rate. Solid dispersion of resveratrol supported on Magnesium DiHydroxide (Resv@MDH) was evaluated to improve solubility and increase bioavailability of resveratrol. Fluorimetric microscopy analysis displays three types of microparticles with similar size: Type 1 that emitted preferably fluorescence at 445 nm with bandwidth of 50 nm, type 2 that emitted preferably fluorescence at 605 nm with bandwidth of 70 nm and type 3 that is non-fluorescent. Micronized pure resveratrol displays only microparticles type 1 whereas type 3 are associated to pure magnesium dihydroxide. Dissolution test in simulated gastric environment resveratrol derived from Resv@MDH in comparison to resveratrol alone displayed better solubility. A 3-fold increase of resveratrol bioavailability was observed after oral administration of 50 mg/kg of resveratrol from Resv@MDH in rabbits. We hypothesize that type 2 microparticles represent magnesium dihydroxide microparticles with a resveratrol shell and that they are responsible for the improved resveratrol solubility and bioavailability of Resv@MDH.

引用

页数：10

共 24 条

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