Stem cell activation in skeletal muscle regeneration

被引:112
作者
Fu, Xin [1 ]
Wang, Huating [2 ]
Hu, Ping [1 ]
机构
[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China
[2] Chinese Univ Hong Kong, Dept Obstet & Gynaecol, Li Ka Shing Inst Hlth Sci, Prince Wales Hosp, Hong Kong, Hong Kong, Peoples R China
基金
中国国家自然科学基金;
关键词
Satellite cells; Quiescent stem cells; Epigenetics; Non-coding RNA; DNA methylation; Growth factors; HEPATOCYTE GROWTH-FACTOR; NITRIC-OXIDE SYNTHASE; DUCHENNE MUSCULAR-DYSTROPHY; STRETCH-INDUCED ACTIVATION; SATELLITE-CELL; GENE-EXPRESSION; MATRIX METALLOPROTEINASES; MYOBLAST PROLIFERATION; NONCODING RNA; IN-VIVO;
D O I
10.1007/s00018-014-1819-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Muscle stem cell (satellite cell) activation post muscle injury is a transient and critical step in muscle regeneration. It is regulated by physiological cues, signaling molecules, and epigenetic regulatory factors. The mechanisms that coherently turn on the complex activation process shortly after trauma are just beginning to be illuminated. In this review, we will discuss the current knowledge of satellite cell activation regulation.
引用
收藏
页码:1663 / 1677
页数:15
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