Myeloid and Lymphoid Neoplasm With Abnormalities of FGFR1 Presenting With Trilineage Blasts and RUNX1 Rearrangement: A Case Report and Review of Literature

Objectives: Myeloid and lymphoid neoplasms with abnormalities of fibroblast growth factor receptor I gene (FGFR1) are a rare and aggressive disease group that harbors translocations 0fFGFR1 with at least 14 recognized partner genes. We report a case of a patient with a novel t(17;21)(p13;q22) with RUNX1 rearrangement and trilineage blasts. Methods: A 29-year-old man with relapsed T-lymphoblastic ' lymphoma in the cervical nodes showed a myeloproliferative neoplasm in his bone marrow with three separate populations of immunophenotypically aberrant myeloid, T-lymphoid, and B-lymphoid blasts by flow cytometry. Cytogenetic and fluorescent in situ hybridization studies showed unique dual translocations of t(8; 13)(p11.2;q12) and t(17;21)(p 13;q22) with RUNX1 rearrangement. Results: The patient was initiated on a mitoxantrone, etoposide, and cytarabine chemotherapy regimen and died of complications of disease I month later. Conclusions: To our knowledge, this is the first reported case of a myeloid and lymphoid neoplasm with abnormalities 0fFGFR1 with t(17;21)(p13;q22) and trilineage blasts.