Palladium(II)-Catalyzed Selective Monofluorination of Benzoic Acids Using a Practical Auxiliary: A Weak-Coordination Approach

被引：166

作者：

Chan, Kelvin S. L. ^{[1
]}

Wasa, Masayuki ^{[1
]}

Wang, Xisheng ^{[1
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Scripps Res Inst TSRI, Dept Chem, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 39期

关键词：

auxiliaries; benzoic acids; C-H activation; fluorination; weak coordination; C-H BONDS; CATALYTIC ENANTIOSELECTIVE FLUORINATION; REDUCTIVE ELIMINATION; ARYLATION; HALOGENATION; IODINATION; CHEMISTRY;

D O I：

10.1002/anie.201102985

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Finally, a choice! A highly selective palladium(II)-catalyzed ortho-monofluorination reaction has been achieved for the first time through a weak coordination (see scheme; Ar=2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl) . Simple modification of this protocol allows for a choice between mono- and difluorination. The mono- and difluorinated benzoic acid derivatives are valuable in the pharmaceutical and agrochemical industries. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9081 / 9084

页数：4

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