Cell-Based Therapy for the Treatment of Glioblastoma: An Update from Preclinical to Clinical Studies

被引：12

作者：

Attia, Noha ^{[1
,2
,3
]}

Mashal, Mohamed ^{[1
,2
]}

Pemminati, Sudhakar ^{[1
]}

Omole, Adekunle ^{[1
]}

Edmondson, Carolyn ^{[1
]}

Jones, Will ^{[1
]}

Priyadarshini, Priyanka ^{[1
]}

Mughal, Temoria ^{[1
]}

Aziz, Pauline ^{[1
]}

Zenick, Blesing ^{[1
]}

Perez, Ambar ^{[1
]}

Lacken, Morgan ^{[1
]}

机构：

[1] Amer Univ Antigua, Coll Med, Coolidge 1451, Antigua & Barbu

[2] Univ Basque Country UPV EHU, Lab Pharmaceut, Nano Bio Cel Grp, Sch Pharm, Paseo Univ 7, Vitoria 01006, Spain

[3] Univ Alexandria, Fac Med, Histol & Cell Biol Dept, Alexandria 21561, Egypt

来源：

CELLS | 2022年 / 11卷 / 01期

关键词：

glioma; stem cell; CAR-T cell; immune cell therapy; cell therapy; cancer; MESENCHYMAL STEM-CELLS; CYTOSINE DEAMINASE GENE; MARROW STROMAL CELLS; T-CELLS; UMBILICAL-CORD; BONE-MARROW; DRUG-DELIVERY; ONCOLYTIC ADENOVIRUS; IMMUNE-RESPONSE; BRAIN-TUMORS;

D O I：

10.3390/cells11010116

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Glioblastoma (GB), an aggressive primary tumor of the central nervous system, represents about 60% of all adult primary brain tumors. It is notorious for its extremely low (~5%) 5-year survival rate which signals the unsatisfactory results of the standard protocol for GB therapy. This issue has become, over time, the impetus for the discipline of bringing novel therapeutics to the surface and challenging them so they can be improved. The cell-based approach in treating GB found its way to clinical trials thanks to a marvelous number of preclinical studies that probed various types of cells aiming to combat GB and increase the survival rate. In this review, we aimed to summarize and discuss the up-to-date preclinical studies that utilized stem cells or immune cells to treat GB. Likewise, we tried to summarize the most recent clinical trials using both cell categories to treat or prevent recurrence of GB in patients. As with any other therapeutics, cell-based therapy in GB is still hampered by many drawbacks. Therefore, we highlighted several novel techniques, such as the use of biomaterials, scaffolds, nanoparticles, or cells in the 3D context that may depict a promising future when combined with the cell-based approach.

引用

页数：28

共 188 条

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