Effectiveness of Mass Drug Administration on Neglected Tropical Diseases in Schoolchildren in Zanzibar, Tanzania

被引:3
作者
Kim, Ju Yeong [1 ,2 ]
Sim, Seobo [3 ]
Chung, Eun Joo [1 ]
Rim, Han-Jong [4 ]
Chai, Jong-Yil [5 ,6 ]
Min, Duk-Young [7 ]
Eom, Keeseon S. [8 ,9 ]
Mohammed, Khalfan A. [10 ]
Khamis, Iddi S. [10 ]
Yong, Tai-Soon [1 ]
机构
[1] Yonsei Univ, Coll Med, Inst Trop Med & Arthropods Med Importance Resourc, Dept Environm Med Biol, Seoul 03722, South Korea
[2] Yonsei Univ, Coll Med, Brain Korea 21 Plus Project Med Sci, Seoul 03722, South Korea
[3] Konkuk Univ, Sch Med, Int Healthcare Res Inst, Dept Environm & Trop Med, Seoul 05029, South Korea
[4] Korea Univ, Coll Med, Dept Parasitol, Seoul 02841, South Korea
[5] Seoul Natl Univ, Coll Med, Dept Trop Med & Parasitol, Seoul 09080, South Korea
[6] Korea Assoc Hlth Promot, Inst Parasit Dis, Seoul 07649, South Korea
[7] Eulji Univ, Coll Med, Dept Microbiol & Immunol, Daejeon 34824, South Korea
[8] Chungbuk Natl Univ, Sch Med, Parasite Resource Bank, Dept Parasitol, Cheongji 28644, South Korea
[9] Chungbuk Natl Univ, Sch Med, Parasite Resource Bank, Med Res Inst, Cheongji 28644, South Korea
[10] Minist Hlth & Social Welf, Integrated Helminth Control Program, Zanzibar, Tanzania
关键词
Schistosoma haematobium; soil-transmitted helminth; neglected tropical disease; mass drug administration; Zanzibar; TRANSMITTED HELMINTH INFECTIONS; PEMBA ISLAND; SCHISTOSOMIASIS; HYGIENE; INTERVENTION; PREVALENCE; SANITATION; MORBIDITY; IMPACT; WATER;
D O I
10.3347/kjp.2020.58.2.109
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Soil-transmitted helminths and Schistosoma haematobium affect more than 3 billion people globally and mainly occur in sub-Saharan Africa. The present study assessed the overall infection status of a 1716-student cohort of school-children in Zanzibar and applied mass drug administration (MDA) to the cohort from 2007 to 2009. Schools in Pemba, Zanzibar, had a much higher prevalence of soil-transmitted helminth infections than those in Unguja, and the Chaani, Ghana, and Machui schools of Unguja exhibited high S. haematobium infection rates. The MDA program only partially controlled parasite infections, owing to high rates of re-infection. The infection rate of S. haematobium across all 10 schools, for example, was only reduced by 1.8%, and even this change not significant, even though the S. haematobium infection rates of the Chaani and Mzambarauni schools were significantly reduced from 64.4 and 23.4%, respectively, at the first screening, to 7.3 and 2.3% at the last screening. The overall infection rate of Ascaris lumbricoides was reduced from 36.0% at the first screening to 22.6% at the last screening. However, the infection rates for both Trichuris trichiura and hookworm were generally unaffected by MDA. In the future, parasite control programs should involve strategically designed MDA schedules and holistic intervention (e.g., sanitation improvement, hygiene behavior changes, and control of intermediated hosts).
引用
收藏
页码:109 / 119
页数:11
相关论文
共 31 条
  • [1] Albonico M, 1997, E AFR MED J, V74, P294
  • [2] [Anonymous], 2015, INV OV GLOB IMP NEGL
  • [3] Interrupting transmission of soil-transmitted helminths: a study protocol for cluster randomised trials evaluating alternative treatment strategies and delivery systems in Kenya
    Brooker, Simon J.
    Mwandawiro, Charles S.
    Halliday, Katherine E.
    Njenga, Sammy M.
    Mcharo, Carlos
    Gichuki, Paul M.
    Wasunna, Beatrice
    Kihara, Jimmy H.
    Njomo, Doris
    Alusala, Dorcas
    Chiguzo, Athuman
    Turner, Hugo C.
    Teti, Caroline
    Gwayi-Chore, Claire
    Nikolay, Birgit
    Truscott, James E.
    Hollingsworth, T. Deirdre
    Balabanova, Dina
    Griffiths, Ulla K.
    Freeman, Matthew C.
    Allen, Elizabeth
    Pullan, Rachel L.
    Anderson, Roy M.
    [J]. BMJ OPEN, 2015, 5 (10):
  • [4] Critical analysis of molluscicide application in schistosomiasis control programs in Brazil
    Coelho, P. M. Z.
    Caldeira, R. L.
    [J]. INFECTIOUS DISEASES OF POVERTY, 2016, 5
  • [5] Crompton D.W.T., 2006, Handbook of Helminthiasis for Public Health
  • [6] Prevalence and intensity of soil-transmitted helminth infections among pre-school age children in 12 kindergartens in Jimma Town, southwest Ethiopia
    Dana, Daniel
    Mekonnen, Zeleke
    Emana, Daniel
    Ayana, Mio
    Getachew, Mestawet
    Workneh, Netsanet
    Vercruysse, Jozef
    Levecke, Bruno
    [J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2015, 109 (03) : 225 - 227
  • [7] Reconsidering the underestimated burden caused by neglected tropical diseases
    Engels, Dirk
    Savioli, Lorenzo
    [J]. TRENDS IN PARASITOLOGY, 2006, 22 (08) : 363 - 366
  • [8] The Impact of a School-Based Hygiene, Water Quality and Sanitation Intervention on Soil-Transmitted Helminth Reinfection: A Cluster-Randomized Trial
    Freeman, Matthew C.
    Clasen, Thomas
    Brooker, Simon J.
    Akoko, Daniel O.
    Rheingans, Richard
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2013, 89 (05) : 875 - 883
  • [9] French Michael D, 2007, J Pediatr Urol, V3, P364, DOI 10.1016/j.jpurol.2007.01.198
  • [10] Schistosomiasis elimination: lessons from the past guide the future
    Gray, Darren J.
    McManus, Donald P.
    Li, Yuesheng
    Williams, Gail M.
    Bergquist, Robert
    Ross, Allen G.
    [J]. LANCET INFECTIOUS DISEASES, 2010, 10 (10) : 733 - 736