Genetic Variants in the ADIPOQ Gene and the Risk of Metabolic Syndrome: A Case-Control Study of a Chinese Han population

被引：9
作者：
Du, Juan [1 ]
Ye, Xin Hua [2 ]
Li, Qian [3 ]
Yu, Xiaofang [4 ]
Cheng, Jinluo [2 ]
Ma, Jianhua [3 ]
Gao, Yanqin [4 ]
Lu, Ying [1 ]
Du, Wencong [1 ]
Shi, Hui [1 ]
Zhao, Xu [1 ]
Ye, Qing [1 ]
Zhou, Ling [1 ]
机构：
[1] Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing 210029, Jiangsu, Peoples R China
[2] NJMU, Affiliated Changzhou Hosp 2, Dept Incret, Changzhou, Jiangsu, Peoples R China
[3] NJMU, Affiliated Nanjing Hosp 1, Dept Incret, Nanjing, Jiangsu, Peoples R China
[4] NJMU, Affiliated Hosp 3, Dept Incret, Yizheng, Jiangsu, Peoples R China
来源：
ANNALS OF HUMAN GENETICS | 2012年 / 76卷
基金：
中国国家自然科学基金;
关键词：
ADIPOQ gene; adiponectin; single nucleotide polymorphism; metabolic syndrome; SINGLE-NUCLEOTIDE POLYMORPHISMS; PLASMA ADIPONECTIN LEVELS; INSULIN-RESISTANCE; SERUM ADIPONECTIN; APM1; GENE; ASSOCIATION ANALYSES; FATTY-ACIDS; PROMOTER; OBESITY; LINKAGE;
D O I：
10.1111/j.1469-1809.2012.00699.x
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Our aim was to investigate whether the ADIPOQ gene polymorphisms are associated with the metabolic syndrome (MetS). Genotypes of MetS patients (n= 1049) and normal controls (n= 1092) were analysed by TaqMan (R) assay, and serum adiponectin concentration was measured by ELISA. The variant genotypes rs266729CG; rs1063539GC, GC/CC; rs1686-1205AA and rs7649121AT, AT/TT (Adjusted P= 0.037, 0.044, 0.025, 0.011, 0.019, 0.020, respectively) of the ADIPOQ gene were associated with MetS. Patients with rs266729CG, CG/GG genotypes (P= 0.034, 0.035) and rs7649121AT, AT/TT genotypes (P= 0.013, 0.022) had higher levels of serum adiponectin than those with the CC and AA genotypes respectively. Furthermore, the prevalence of haplotypes GGAAAATC and GGGTAACC was lower in cases (10.7% and 4.5%) than in controls (12.1% and 5.9%) [Adjusted ORs (95% CIs) = 0.70 (0.54-0.91), 0.65 (0.46-0.92)]. The ADIPOQ gene variants associated with the risk of MetS in this study must be validated by further functional studies to reveal any potential effects on metabolism.
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收藏
页码：101 / 109
页数：9
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