Role of Nitric Oxide and Protein S-Nitrosylation in Ischemia-Reperfusion Injury

被引：11
|
作者：
Lee, Hyang-Mi [1 ]
Choi, Ji Woong [2 ]
Choi, Min Sik [3 ]
机构：
[1] Dongduk Womens Univ, Coll Pharm, Seoul 02748, South Korea
[2] Gachon Univ, Coll Pharm, Incheon 21936, South Korea
[3] Dongduk Womens Univ, Coll Pharm, Lab Pharmacol, Seoul 02748, South Korea
来源：
ANTIOXIDANTS | 2022年 / 11卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
ischemia-reperfusion injury; nitric oxide; protein S-nitrosylation; ADHESION MOLECULE EXPRESSION; DECREASES INFARCTION SIZE; REGULATING KINASE 1; MYOCARDIAL-ISCHEMIA; LIVER ISCHEMIA; KAPPA-B; ENDOTHELIAL DYSFUNCTION; L-ARGININE; NEUTROPHIL INFILTRATION; SODIUM-NITROPRUSSIDE;
D O I：
10.3390/antiox11010057
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ischemia-reperfusion injury (IRI) is a process in which damage is induced in hypoxic tissue when oxygen supply is resumed after ischemia. During IRI, restoration of reduced nitric oxide (NO) levels may alleviate reperfusion injury in ischemic organs. The protective mechanism of NO is due to anti-inflammatory effects, antioxidant effects, and the regulation of cell signaling pathways. On the other hand, it is generally known that S-nitrosylation (SNO) mediates the detrimental or protective effect of NO depending on the action of the nitrosylated target protein, and this is also applied in the IRI process. In this review, the effect of each change of NO and SNO during the IRI process was investigated.
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页数：14
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