Genetics of structural and functional brain changes in autism spectrum disorder

被引：92

作者：

Hashem, Sheema ^{[1
]}

Nisar, Sabah ^{[1
]}

Bhat, Ajaz A. ^{[1
]}

Yadav, Santosh Kumar ^{[1
]}

Azeem, Muhammad Waqar ^{[2
]}

Bagga, Puneet ^{[3
]}

Fakhro, Khalid ^{[4
,5
]}

Reddy, Ravinder ^{[3
]}

Frenneaux, Michael P. ^{[6
]}

Haris, Mohammad ^{[1
,7
]}

机构：

[1] Sidra Med, Funct & Mol Imaging Lab, Doha, Qatar

[2] Sidra Med, Dept Psychiat, Doha, Qatar

[3] Univ Penn, Perelman Sch Med, Dept Radiol, Ctr Magnet Resonance & Opt Imaging, Philadelphia, PA 19104 USA

[4] Sidra Med, Dept Human Genet, Doha, Qatar

[5] Weill Cornell Med Coll, Dept Genet Med, Doha, Qatar

[6] Hamad Med Corp, Acad Hlth Syst, Doha, Qatar

[7] Qatar Univ, Lab Anim Res Ctr, Doha, Qatar

来源：

TRANSLATIONAL PSYCHIATRY | 2020年 / 10卷 / 01期

关键词：

OXYTOCIN RECEPTOR GENE; CORTICAL THICKNESS; CEREBELLAR STRUCTURE; PREFRONTAL CORTEX; IMAGING GENETICS; COWDEN-SYNDROME; WORKING-MEMORY; YOUNG-CHILDREN; COMMON ALLELE; WHITE-MATTER;

D O I：

10.1038/s41398-020-00921-3

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Autism spectrum disorder (ASD) is a neurological and developmental disorder characterized by social impairment and restricted interactive and communicative behaviors. It may occur as an isolated disorder or in the context of other neurological, psychiatric, developmental, and genetic disorders. Due to rapid developments in genomics and imaging technologies, imaging genetics studies of ASD have evolved in the last few years. Increased risk for ASD diagnosis is found to be related to many specific single-nucleotide polymorphisms, and the study of genetic mechanisms and noninvasive imaging has opened various approaches that can help diagnose ASD at the nascent level. Identifying risk genes related to structural and functional changes in the brain of ASD patients provide a better understanding of the disease's neuropsychiatry and can help identify targets for therapeutic intervention that could be useful for the clinical management of ASD patients.

引用

页数：17

共 149 条

[1] Deriving reproducible biomarkers from multi-site resting-state data: An Autism-based example [J].