Inflammation and HIV Transmission in Sub-Saharan Africa

被引：48

作者：

Kaul, Rupert ^{[1
,2
,3
]}

Prodger, Jessica ^{[1
,4
]}

Joag, Vineet ^{[1
]}

Shannon, Brett ^{[1
]}

Yegorov, Sergey ^{[1
]}

Galiwango, Ronald ^{[1
]}

McKinnon, Lyle ^{[5
]}

机构：

[1] Univ Toronto, Dept Med & Immunol, Toronto, ON M5S 1A8, Canada

[2] Univ Nairobi, Dept Med Microbiol, Nairobi, Kenya

[3] Univ Hlth Network, Toronto, ON, Canada

[4] Johns Hopkins Univ, Baltimore, MD USA

[5] Ctr AIDS Programme Res South Africa CAPRISA, Durban, South Africa

来源：

CURRENT HIV/AIDS REPORTS | 2015年 / 12卷 / 02期

关键词：

HIV transmission; Sub-Saharan Africa; Mucosal immunology; Inflammation; Co-infections; HUMAN-IMMUNODEFICIENCY-VIRUS; SEXUALLY-TRANSMITTED INFECTIONS; CD4(+) T-CELLS; BACTERIAL VAGINOSIS; IMMUNE ACTIVATION; GENITAL-TRACT; MALE CIRCUMCISION; HORMONAL CONTRACEPTIVES; YOUNG-WOMEN; TH17; CELLS;

D O I：

10.1007/s11904-015-0269-5

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

While the per-contact risk of sexual HIV transmission is relatively low, it is fourfold higher in sub-Saharan Africa, and this may partly explain the major global disparities that exist in HIV prevalence. Genital immune parameters are key determinants of HIV transmission risk, including epithelial integrity and the presence of highly HIV-susceptible intraepithelial or submucosal CD4+ T cell target cells. Biological parameters that may enhance mucosal HIV susceptibility in highly HIV-affected regions of sub-Saharan Africa include increased levels of mucosal inflammation, which can affect both epithelial integrity and target cell availability, as well as the increased mucosal surface area that is afforded by an intact foreskin, contraceptive choices, and intravaginal practices. There are multifactorial causes for increased mucosal inflammation, with the prevalence and nature of common co-infections being particularly relevant.

引用

页码：216 / 222

页数：7

共 94 条

[51] Foreskin surface area and HIV acquisition in Rakai, Uganda (size matters) [J].

Kigozi, Godfrey ;

Wawer, Maria ;

Ssettuba, Absalom ;

Kagaayi, Joseph ;

Nalugoda, Fred ;

Watya, Stephen ;

Mangen, Fred Wabwire ;

Kiwanuka, Noah ;

Bacon, Melanie C. ;

Lutalo, Tom ;

Serwadda, David ;

Gray, Ronald H. .

AIDS, 2009, 23 (16) :2209-2213

[52] Effect of Female Genital Schistosomiasis and Anti-Schistosomal Treatment on Monocytes, CD4+ T-Cells and CCR5 Expression in the Female Genital Tract [J].

Kleppa, Elisabeth ;

Ramsuran, Veron ;

Zulu, Siphosenkosi ;

Karlsen, Gunn Hege ;

Bere, Alfred ;

Passmore, Jo-Ann S. ;

Ndhlovu, Patricia ;

Lillebo, Kristine ;

Holmen, Sigve D. ;

Onsrud, Mathias ;

Gundersen, Svein Gunnar ;

Taylor, Myra ;

Kjetland, Eyrun F. ;

Ndung'u, Thumbi .

PLOS ONE, 2014, 9 (06)

[53] Elevation of immune activation in Kenyan women is associated with alterations in immune function: Implications for vaccine development [J].

Koesters, SA ;

Matu, L ;

Kiama, P ;

Anzala, O ;

Embree, J ;

Plummer, FA ;

Kimani, J ;

Fowke, KR .

JOURNAL OF CLINICAL IMMUNOLOGY, 2004, 24 (06) :702-709

[54] A distinct cytokine and chemokine profile at the genital mucosa is associated with HIV-1 protection among HIV-exposed seronegative commercial sex workers [J].

Lajoie, J. ;

Juno, J. ;

Burgener, A. ;

Rahman, S. ;

Mogk, K. ;

Wachihi, C. ;

Mwanjewe, J. ;

Plummer, F. A. ;

Kimani, J. ;

Ball, T. B. ;

Fowke, K. R. .

MUCOSAL IMMUNOLOGY, 2012, 5 (03) :277-287

[55] Levels of innate immune factors in genital fluids: association of alpha defensins and LL-37 with genital infections and increased HIV acquisition [J].

Levinson, Pauline ;

Kaul, Rupert ;

Kimani, Joshua ;

Ngugi, Elizabeth ;

Moses, Stephen ;

MacDonald, Kelly S. ;

Broliden, Kristina ;

Hirbod, Taha .

AIDS, 2009, 23 (03) :309-317

[56] The Semen Microbiome and Its Relationship with Local Immunology and Viral Load in HIV Infection [J].

Liu, Cindy M. ;

Osborne, Brendan J. W. ;

Hungate, Bruce A. ;

Shahabi, Kamnoosh ;

Huibner, Sanja ;

Lester, Richard ;

Dwan, Michael G. ;

Kovacs, Colin ;

Contente-Cuomo, Tania L. ;

Benko, Erika ;

Aziz, Maliha ;

Price, Lance B. ;

Kaul, Rupert .

PLOS PATHOGENS, 2014, 10 (07)

[57] Intravaginal Practices, Bacterial Vaginosis, and HIV Infection in Women: Individual Participant Data Meta-analysis [J].

Low, Nicola ;

Chersich, Matthew F. ;

Schmidlin, Kurt ;

Egger, Matthias ;

Francis, Suzanna C. ;

van de Wijgert, Janneke H. H. M. ;

Hayes, Richard J. ;

Baeten, Jared M. ;

Brown, Joelle ;

Delany-Moretlwe, Sinead ;

Kaul, Rupert ;

McGrath, Nuala ;

Morrison, Charles ;

Myer, Landon ;

Temmerman, Marleen ;

van der Straten, Ariane ;

Watson-Jones, Deborah ;

Zwahlen, Marcel ;

Hilber, Adriane Martin .

PLOS MEDICINE, 2011, 8 (02)

[58] Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: a cross-sectional study [J].

Masson, Lindi ;

Mlisana, Koleka ;

Little, Francesca ;

Werner, Lise ;

Mkhize, Nonhlanhla N. ;

Ronacher, Katharina ;

Gamieldien, Hoyam ;

Williamson, Carolyn ;

Mckinnon, Lyle R. ;

Walzl, Gerhard ;

Karim, Quarraisha Abdool ;

Karim, Salim S. Abdool ;

Passmore, Jo-Ann S. .

SEXUALLY TRANSMITTED INFECTIONS, 2014, 90 (08) :580-U21

[59] Quality and quantity: mucosal CD4+ T cells and HIV susceptibility [J].

McKinnon, Lyle R. ;

Kaul, Rupert .

CURRENT OPINION IN HIV AND AIDS, 2012, 7 (02) :195-202

[60] Characterization of a Human Cervical CD4+ T Cell Subset Coexpressing Multiple Markers of HIV Susceptibility [J].

McKinnon, Lyle R. ;

Nyanga, Billy ;

Chege, Duncan ;

Izulla, Preston ;

Kimani, Makobu ;

Huibner, Sanja ;

Gelmon, Lawrence ;

Block, Katharine E. ;

Cicala, Claudia ;

Anzala, A. Omu ;

Arthos, James ;

Kimani, Joshua ;

Kaul, Rupert .

JOURNAL OF IMMUNOLOGY, 2011, 187 (11) :6032-6042

← 1 2 3 4 5 6 7 8 9 10 →