Multi-wavelength photo-acoustic microscopy in the frequency domain for simultaneous excitation and detection of dyes

被引：9

作者：

Hugon, Olivier ^{[1
]}

van der Sanden, Boudewijn ^{[2
]}

Inglebert, Mehdi ^{[1
]}

Jacquin, Olivier ^{[1
]}

Misbah, Chaouqi ^{[1
]}

Lacot, Eric ^{[1
]}

机构：

[1] Univ Grenoble Alpes, CNRS, LiPhy, F-38000 Grenoble, France

[2] Univ Grenoble Alpes, CNRS, TIMC IMAG UMR 5525, La Tronche, France

来源：

BIOMEDICAL OPTICS EXPRESS | 2019年 / 10卷 / 02期

关键词：

D O I：

10.1364/BOE.10.000932

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

An optical-resolution photoacoustic microscope with modulated CW laser diodes allowing multi-channel imaging is presented that can be used for both imaging biological tissues and for targeted photo-dynamic therapy (PDT) varying the optical power and exposure time. The effects of this therapy are immediately monitored in order to optimize the time of irradiation. After the description of the experimental setup, in vitro and in vivo applications are presented on a synthetic sample and on the mouse ear using hemoglobin as endogenous and methylene blue as exogenous dye for imaging and PDT, respectively. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

引用

页码：932 / 943

页数：12

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