Lineage Tracing

被引：494

作者：

Kretzschmar, Kai ^{[1
]}

Watt, Fiona M. ^{[1
,2
]}

机构：

[1] Univ Cambridge, Wellcome Trust Ctr Stem Cell Res, Cambridge CB2 1QR, England

[2] Li Ka Shing Ctr, Canc Res UK Cambridge Res Inst, Cambridge CB2 0RE, England

来源：

CELL | 2012年 / 148卷 / 1-2期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

FOLLICLE STEM-CELLS; LABEL-RETAINING CELLS; HAIR FOLLICLE; ESTROGEN-RECEPTOR; MOUSE EPIDERMIS; CRE RECOMBINASE; SMALL-INTESTINE; NERVOUS-SYSTEM; REPORTER MOUSE; GENE-TRANSFER;

D O I：

10.1016/j.cell.2012.01.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lineage tracing is the identification of all progeny of a single cell. Although its origins date back to developmental biology of invertebrates in the 19th century, lineage tracing is now an essential tool for studying stem cell properties in adult mammalian tissues. Lineage tracing provides a powerful means of understanding tissue development, homeostasis, and disease, especially when it is combined with experimental manipulation of signals regulating cell-fate decisions. Recently, the combination of inducible recombinases, multicolor reporter constructs, and live-cell imaging has provided unprecedented insights into stem cell biology. Here we discuss the different experimental strategies currently available for lineage tracing, their associated caveats, and new opportunities to integrate lineage tracing with the monitoring of intracellular signaling pathways.

引用

页码：33 / 45

页数：13

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