Lanthanum doped octacalcium phosphate/polylactic acid scaffold fabricated by 3D printing for bone tissue engineering

被引:19
作者
Xu, Zeya [1 ,2 ]
Lin, Bin [3 ]
Zhao, Chaoqian [1 ]
Lu, Yanjin [1 ]
Huang, Tingting [1 ]
Chen, Yan [1 ,2 ]
Li, Jungang [3 ]
Wu, Rongcan [3 ]
Liu, Wenge [3 ]
Lin, Jinxin [1 ,2 ]
机构
[1] Chinese Acad Sci, Fujian Inst Res Struct Matter, Key Lab Optoelect Mat Chem & Phys, 155 West Yangqiao Rd, Fuzhou 350002, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Fujian Med Univ Union Hosp, Orthoped Dept, Fuzhou 350001, Peoples R China
来源
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY | 2022年 / 118卷
基金
中国国家自然科学基金;
关键词
Lanthanum; Octacalcium phosphate; Scaffold; 3D printing; Bone tissue engineering; Polylactic acid; OSTEOGENIC DIFFERENTIATION; CALCIUM HYDROXYAPATITES; CERAMIC SCAFFOLDS; METAL-IONS; PHOSPHATE; IRON; BIOMATERIALS; REGENERATION; RESORPTION; CARBONATE;
D O I
10.1016/j.jmst.2021.09.069
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Lanthanum (La) has tremendous potential in the treatment and prevention of bone diseases especially osteoporosis and metabolic disorders. However, controlling its distribution and keeping the release of La3+ ions sustained and steady in the body is still a big challenge. In this study, we prepared La-OCP powders via co-precipitation method, and further prepared La-OCP/PLA porous scaffolds by 3D printing. La3+ was successfully introduced into the OCP crystal structure and substituted Ca2+ at the Ca-5 and Ca-8 sites. In particular, some La3+ ions were deposited on the crystal surface in the form of nanoparticles. Both octacalcium phosphate (OCP, Ca8H2(PO4)(6)center dot 5H(2)O) crystals and nanoparticles played as the carriers for La3+ ions. The La-OCP/PLA scaffolds displayed obvious mineralization effects and sustained release of La3+. The scaffolds contained a uniform structure with rough micro surface topography which acted as a suitable pathway for BMSCs cells to adhere, grow and proliferation. At a certain La3+ concentration, the extracts from La-OCP/PLA scaffolds increased the expression of osteogenesis-related genes, thus promoting the osteogenic differentiation of BMSCs. Moreover, the extracts regulated the immune responses. The experiment in vivo proved that La-OCP/PLA porous scaffolds were safe and could enhance bone defect regeneration in vivo. These findings suggest that 3D printed La-OCP/PLA porous scaffolds have promising potentials in bone tissue engineering. (C) 2022 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
引用
收藏
页码:229 / 242
页数:14
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