The association of urinary prostaglandins with uric acid in hyperuricemia patients

Purpose: To explore the association between uric acid and urinary prostaglandins in male patients with hyperuricemia. Methods: A total of 38 male patients with hyperuricemia in outpatients of Huadong Hospital from July 2018 to January 2020 were recruited. Serum uric acid (SUA), 24 h urinary uric acid excretion and other indicators were detected respectively. 10 ml urine was taken to determine prostaglandin prostaglandin D (PGD), prostaglandin E1 (PGE1), prostaglandin E2 (PGE2), 6-keto-PGF1 alpha, thromboxane A2 (TXA2) and thromboxane B2 (TXB2). Fraction of uric acid excretion (FEua) and uric acid clearance rate (Cua) were calculated. According to the mean value of FEua and Cua, patients were divided into two groups, respectively. The independent-samples t test and the Mann-Whitney U test were applied for normally and non-normally distributed data, respectively. Results: After adjusting confounding factors (age, BMI, eGFR,TG,TC, HDL and LDL), SUA was negatively correlated with urinary PGE1(r= -0.615, P=0.009) and PGE2(r= -0.824, P< 0.001). Compared with SUA1 group (SUA < 482.6 mg/dl), SUA2 (SUA >= 482.6 mg/dl) had lower urinary PGE1(P= 0.022) and PGE2(P= 0.019) levels. Cua was positively correlated with PGE2 (r= 0.436, P= 0.01). The correlation persisted after adjustment for age, BMI, eGFR,TG,TC, HDL and LDL by multiple linear regression analysis. In the Cua1 group (Cua < 4.869 mL /min/1.73 m(2)), PGE2 were lower than that in Cua2 (Cua >= 4.869 mL /min/1.73 m(2)) group (P=0.011). Conclusions: In male patients with hyperuricemia, SUA was negatively correlated with urinary PGE2, Cua was positively correlated with urinary PGE2. Urinary PGE2 were significantly different between different SUA and Cua groups.