Micro-RNAs: targets for enhancing osteoblast differentiation and bone formation

被引：117

作者：

Taipaleenmaki, Hanna ^{[1
,2
]}

Hokland, Lea Bjerre ^{[1
]}

Chen, Li ^{[1
]}

Kauppinen, Sakari ^{[3
,4
]}

Kassem, Moustapha ^{[1
,5
]}

机构：

[1] Univ So Denmark, Odense Univ Hosp, Dept Endocrinol & Metab, Mol Endocrinol Lab KMEB,Med Biotechnol Ctr,SDU, DK-5000 Odense C, Denmark

[2] Univ Turku, Dept Med Biochem & Genet, Turku, Finland

[3] Santaris Pharma, DK-2970 Horsholm, Denmark

[4] Aalborg Univ, Copenhagen Inst Technol, DK-2750 Ballerup, Denmark

[5] King Saud Univ, Coll Med, Stem Cell Unit, Dept Anat, Riyadh, Saudi Arabia

来源：

EUROPEAN JOURNAL OF ENDOCRINOLOGY | 2012年 / 166卷 / 03期

关键词：

MESENCHYMAL STEM-CELLS; HUMAN ADIPOSE-TISSUE; FOCAL ADHESION KINASE; OSTEOGENIC DIFFERENTIATION; RHEUMATOID-ARTHRITIS; SIGNALING PATHWAYS; MESSENGER-RNAS; NUCLEAR EXPORT; BINDING-SITES; STROMAL CELLS;

D O I：

10.1530/EJE-11-0646

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Osteoblast differentiation and bone formation (osteogenesis) are regulated by transcriptional and post-transcriptional mechanisms. Recently, a novel class of regulatory factors termed micro-RNAs (miRNAs) has been identified as playing an important role in the regulation of many aspects of osteoblast biology including proliferation, differentiation, metabolism and apoptosis. Also, preliminary data from animal disease models suggest that targeting miRNAs in bone can be a novel approach to increase bone mass. This review highlights the current knowledge of miRNA biology and their role in bone formation and discusses their potential use in future therapeutic applications for metabolic bone diseases.

引用

页码：359 / 371

页数：13

共 140 条

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