Multiple chromosomal monosomies are characteristic of giant cell ependymoma

被引：8

作者：

Dahlback, Hanne-Sofie S. ^{[1
,2
,3
]}

Brandal, Petter ^{[1
,2
,4
]}

Krossnes, Bard K. ^{[5
]}

Fric, Radek ^{[6
]}

Meling, Torstein R. ^{[6
]}

Meza-Zepeda, Leonardo A. ^{[7
,8
]}

Danielsen, Havard E. ^{[2
,9
,10
]}

Heim, Sverre ^{[1
,2
,3
]}

机构：

[1] Norwegian Radium Hosp, Oslo Univ Hosp, Inst Med Informat, Sect Canc Cytogenet, N-0310 Oslo, Norway

[2] Univ Oslo, Ctr Canc Biomed, N-0310 Oslo, Norway

[3] Univ Oslo, Fac Med, Inst Clin Med, N-0316 Oslo, Norway

[4] Oslo Univ Hosp, Norwegian Radium Hosp, Div Canc & Surg, Dept Oncol, N-0316 Oslo, Norway

[5] Oslo Univ Hosp, Rikshosp, Dept Pathol, N-0372 Oslo, Norway

[6] Oslo Univ Hosp, Rikshosp, Dept Neurosurg, N-0372 Oslo, Norway

[7] Oslo Univ Hosp, Norwegian Radium Hosp, Dept Tumor Biol, N-0310 Oslo, Norway

[8] Univ Oslo, Dept Mol Biosci, Norwegian Microarray Consortium, N-0310 Oslo, Norway

[9] Oslo Univ Hosp, Norwegian Radium Hosp, Inst Med Informat, N-0310 Oslo, Norway

[10] Univ Oslo, Dept Informat, N-0316 Oslo, Norway

来源：

HUMAN PATHOLOGY | 2011年 / 42卷 / 12期

关键词：

Giant cell ependymoma; Anaplastic ependymoma; Karyotyping; Aneuploidy; DNA ploidy analysis; Array comparative genomic hybridization; OF-THE-LITERATURE;

D O I：

10.1016/j.humpath.2011.02.012

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Giant cell ependymoma, a rare ependymoma subtype, was recently recognized as a separate diagnostic entity with variations both in malignant potential and course of disease. We analyzed the first supratentorial giant cell ependymoma using G-band karyotyping, DNA ploidy analysis, and array comparative genomic hybridization. The tumor was hypodiploid, and the karyotype showed multiple monosomies. This novel cytogenetic pattern seems specific for giant cell ependymoma as the only previous cytogenetic analysis of a giant cell ependymoma found similar monosomies. We were also able to analyze cytogenetically the subsequent recurrent tumor, phenotypically an anaplastic ependymoma, allowing a first insight into the genetic events involved in disease progression. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：2042 / 2046

页数：5

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