Behaviour in amyotrophic lateral sclerosis

被引:79
作者
Gibbons, Zoe C. [1 ]
Richardson, Anna [1 ]
Neary, David [1 ]
Snowden, Julie S. [1 ]
机构
[1] Hope Hosp, Cerebral Funct Unit, Greater Manchester Neurosci Ctr, Salford M6 8HD, Lancs, England
来源
AMYOTROPHIC LATERAL SCLEROSIS | 2008年 / 9卷 / 02期
关键词
behaviour; amyotrophic lateral sclerosis; motor neuron disease; frontotemporal dementia;
D O I
10.1080/17482960701642437
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We wished to determine whether patients with amyotrophic lateral sclerosis (ALS) show behavioural changes similar to those of frontotemporal dementia (FTD). There is accumulating evidence to suggest a link between ALS and FTD, yet there has been little systematic exploration of behaviour in ALS. An informant based semi-structured behavioural interview, sensitive to the behavioural changes of FTD, was administered to carets of 16 consecutive patients attending a motor neuron disease clinic. Findings varied across the group. At one extreme informants reported no behavioural change, whereas at the other they reported a spectrum of behaviours similar to those seen in FTD. Changes in affect and social behaviour were most common, although some patients also showed altered response to sensory stimuli, gluttony and indiscriminate eating, behavioural stereotypies and compulsions. Behavioural changes were mirrored by SPECT abnormalities in the frontal and/or temporal lobes. Thus, behavioural changes of the type seen in FTD may be present even in a small consecutive cohort of ALS patients. Detection of behavioural change is crucial for optimal management.
引用
收藏
页码:67 / 74
页数:8
相关论文
共 50 条
[21]   The diagnosis of Amyotrophic Lateral Sclerosis [J].
Silani, V. ;
Messina, S. ;
Poletti, B. ;
Morelli, C. ;
Doretti, A. ;
Ticozzi, N. ;
Maderna, L. .
ARCHIVES ITALIENNES DE BIOLOGIE, 2011, 149 (01) :5-27
[22]   Amyotrophic lateral sclerosis: an update [J].
Prida Javier, Marin .
REVISTA MEXICANA DE NEUROCIENCIA, 2009, 10 (04) :281-286
[23]   Diagnosis of amyotrophic lateral sclerosis [J].
Rowland, LP .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1998, 160 :S6-S24
[24]   Amyotrophic lateral sclerosis mimics [J].
Kwan, Justin ;
Vullaganti, Mithila .
MUSCLE & NERVE, 2022, 66 (03) :240-252
[25]   Genetics of Amyotrophic Lateral Sclerosis [J].
Jenna M. Gregory ;
Delphine Fagegaltier ;
Hemali Phatnani ;
Matthew B. Harms .
Current Genetic Medicine Reports, 2020, 8 :121-131
[26]   Amyotrophic Lateral Sclerosis Model [J].
Azuma, Yumiko ;
Mizuta, Ikuko ;
Tokuda, Takahiko ;
Mizuno, Toshiki .
DROSOPHILA MODELS FOR HUMAN DISEASES, 2018, 1076 :79-95
[27]   Amyotrophic lateral sclerosis: update [J].
Hugo Zapata-Zapata, Carlos ;
Franco-Dager, Edwing ;
Marcos Solano-Atehortua, Juan ;
Fernanda Ahunca-Velasquez, Luisa .
IATREIA, 2016, 29 (02) :194-205
[28]   Amygdala pathology in amyotrophic lateral sclerosis and primary lateral sclerosis [J].
Chipika, Rangariroyashe H. ;
Christidi, Foteini ;
Finegan, Eoin ;
Shing, Stacey Li Hi ;
McKenna, Mary Clare ;
Chang, Kai Ming ;
Karavasilis, Efstratios ;
Doherty, Mark A. ;
Hengeveld, Jennifer C. ;
Vajda, Alice ;
Pender, Niall ;
Hutchinson, Siobhan ;
Donaghy, Colette ;
McLaughlin, Russell L. ;
Hardiman, Orla ;
Bede, Peter .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2020, 417
[29]   Genetic analysis of matrin 3 gene in French amyotrophic lateral sclerosis patients and frontotemporal lobar degeneration with amyotrophic lateral sclerosis patients [J].
Millecamps, Stephanie ;
De Septenville, Anne ;
Teyssou, Elisa ;
Daniau, Mailys ;
Camuzat, Agnes ;
Albert, Melanie ;
LeGuern, Eric ;
Galimberti, Daniela ;
Brice, Alexis ;
Marie, Yannick ;
Le Ber, Isabelle .
NEUROBIOLOGY OF AGING, 2014, 35 (12) :2882.e13-2882.e15
[30]   VCP mutations in familial and sporadic amyotrophic lateral sclerosis [J].
Koppers, Max ;
van Blitterswijk, Marka M. ;
Vlam, Lotte ;
Rowicka, Paulina A. ;
van Vught, Paul W. J. ;
Groen, Ewout J. N. ;
Spliet, Wim G. M. ;
Engelen-Lee, JooYeon ;
Schelhaas, Helenius J. ;
de Visser, Marianne ;
van der Kooi, Anneke J. ;
van der Pol, W-Ludo ;
Pasterkamp, R. Jeroen ;
Veldink, Jan H. ;
van den Berg, Leonard H. .
NEUROBIOLOGY OF AGING, 2012, 33 (04) :837.e7-837.e13