Insight into the heterogeneity of breast cancer through next-generation sequencing

被引：187

作者：

Russnes, Hege G. ^{[1
,2
,3
,4
,5
]}

Navin, Nicholas ^{[6
,7
]}

Hicks, James ^{[8
]}

Borresen-Dale, Anne-Lise ^{[1
,3
]}

机构：

[1] Oslo Univ Hosp, Dept Genet, Inst Canc Res, Oslo, Norway

[2] Oslo Univ Hosp, Div Pathol, Lab Mol Pathol, Oslo, Norway

[3] Univ Oslo, Inst Clin Med, Oslo, Norway

[4] Harvard Univ, Sch Med, Boston, MA USA

[5] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[6] Univ Texas MD Anderson Canc Ctr, Dept Genet, Houston, TX 77030 USA

[7] Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA

[8] Cold Spring Harbor Labs, Cold Spring Harbor, NY USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2011年 / 121卷 / 10期

关键词：

COMPARATIVE GENOMIC HYBRIDIZATION; GENE-EXPRESSION PATTERNS; BONE-MARROW MICROMETASTASIS; DNA METHYLATION PATTERNS; TUMOR HETEROGENEITY; MOLECULAR SUBTYPES; SINGLE CELLS; ESOPHAGEAL ADENOCARCINOMA; KARYOTYPIC COMPARISONS; CLONAL HETEROGENEITY;

D O I：

10.1172/JCI57088

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Rapid and sophisticated improvements in molecular analysis have allowed us to sequence whole human genomes as well as cancer genomes, and the findings suggest that we may be approaching the ability to individualize the diagnosis and treatment of cancer. This paradigmatic shift in approach will require clinicians and researchers to overcome several challenges including the huge spectrum of tumor types within a given cancer, as well as the cell-to-cell variations observed within tumors. This review discusses how next-generation sequencing of breast cancer genomes already reveals insight into tumor heterogeneity and how it can contribute to future breast cancer classification and management.

引用

页码：3810 / 3818

页数：9

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