Detection of seven Alternaria toxins in edible and medicinal herbs using ultra-high performance liquid chromatography-tandem mass spectrometry

被引：30
作者：
Zhao, Xiangsheng [1 ,2 ]
Liu, Dan [1 ,2 ]
Yang, Xinquan [1 ,2 ]
Zhang, Lei [3 ]
Yang, Meihua [1 ,2 ,4 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, Key Lab Resources Conservat & Dev Southern Med Ha, Haikou 570311, Hainan, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Hainan Branch, 4,Yaogu 4 Rd, Haikou 570311, Hainan, Peoples R China
[3] Guangdong Pharmaceut Univ, Sch Tradit Chinese Med, Guangzhou 510006, Peoples R China
[4] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, 151 Malianwa North Rd, Beijing 100193, Peoples R China
来源：
FOOD CHEMISTRY-X | 2022年 / 13卷
基金：
中国国家自然科学基金;
关键词：
Alternaria; Herbs; Mycotoxin; Occurrence; UPLC-MS; MS; QuEChERS; SOLID-PHASE EXTRACTION; ALTERNARIA MYCOTOXINS; QUANTIFICATION; PRODUCTS; FRUITS; WINE;
D O I：
10.1016/j.fochx.2021.100186
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Alternaria mycotoxins are ubiquitous mycotoxins that contaminate food and animal feed. Here, an UPLC-MS/MS was developed and used for the detection of seven Alternaria mycotoxins in 19 different edible and medicinal herbs. Extensive optimization resulted in a simple and convenient sample preparation procedure with satisfac-tory extraction and a lower matrix effect. LOQs ranged from 0.01 to 2.0 ng/mL. Recoveries varied between 71.44% and 112.65%, with RSD less than 12%. The method was successfully applied for use in the mycotoxin analysis of 260 samples. A high percentage (28.46%) of samples were contaminated by 1-5 mycotoxins. Alternariol mono methylether was the predominant mycotoxin with high percentage of positive samples (37.5%), followed by alternariol (22.5%), alternariol (17.5%), tentoxin (10.83%), altertoxin I (7.5%), and altenusin (4.17%). Collectively, the natural incidence data obtained from this study will help with better, vali-dated risk assessments and efforts towards more comprehensive, future regulation.
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页数：9
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