Mediators of reprogramming: transcription factors and transitions through mitosis

被引：161

作者：

Egli, Dieter

Birkhoff, Garrett

Eggan, Kevin ^{[1
]}

机构：

[1] Harvard Univ, Stowers Med Inst, Harvard Stem Cell Inst, Cambridge, MA 02138 USA

[2] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2008年 / 9卷 / 07期

关键词：

D O I：

10.1038/nrm2439

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

It is thought that most cell types of the human body share the same genetic information as that contained in the zygote from which they originate. Consistent with this view, animal cloning studies demonstrated that the intact genome of a differentiated cell can be reprogrammed to support the development of an entire organism and allow the production of pluripotent stem cells. Recent progress in reprogramming research now points to an important role for transcription factors in the establishment and the maintenance of cellular phenotypes, and to cell division as a mediator of transitions between different states of gene expression.

引用

页码：505 / 516

页数：12

共 165 条

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