Temporal cortex dopamine D2/3 receptor binding in major depression

被引：20

作者：

Lehto, Soili M. ^{[1
]}

Kuikka, Jyrki ^{[2
]}

Tolmunen, Tommi ^{[1
]}

Hintikka, Jukka ^{[1
,5
]}

Viinamaki, Heimo ^{[1
]}

Vanninen, Ritva ^{[3
]}

Haatainen, Kaisa ^{[1
]}

Koivumaa-Honkanen, Heli ^{[1
]}

Honkalampi, Kirsi ^{[1
]}

Tiihonen, Jari ^{[4
]}

机构：

[1] Kuopio Univ Hosp, Dept Psychiat, SF-70210 Kuopio, Finland

[2] Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, SF-70210 Kuopio, Finland

[3] Kuopio Univ Hosp, Dept Clin Radiol, SF-70210 Kuopio, Finland

[4] Univ Kuopio, Niuvanniemi Hosp, Dept Forens Psychiat, FIN-70211 Kuopio, Finland

[5] Paijat Hame Cent Hosp, Dept Psychiat, Lahti, Finland

来源：

PSYCHIATRY AND CLINICAL NEUROSCIENCES | 2008年 / 62卷 / 03期

关键词：

I-123] epidepride; depression; dopamine; single-photon emission computed tomography; temporal cortex;

D O I：

10.1111/j.1440-1819.2008.01814.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aim of this study was to assess the dopamine function of the temporal cortex in major depressive disorder using [I-123]epidepride to image D-2/3 receptor binding sites. Ten major depressives and 10 healthy controls were selected from a general population sample for single-photon emission computed tomography imaging. Among the major depressives there was a strong bilateral correlation between the scores on the 21-item Hamilton Depression Rating Scale and D-2/3 receptor binding. Dopaminergic abnormalities may be present in the temporal cortices of major depressives.

引用

页码：345 / 348

页数：4

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