Higher frequency but random distribution of EGFR mutation subtypes in familial lung cancer patients

被引：13

作者：

Hsu, Kuo-Hsuan ^{[1
,2
]}

Tseng, Jeng-Sen ^{[3
,4
]}

Wang, Chih-Liang ^{[5
,6
]}

Yang, Tsung-Ying ^{[3
,4
]}

Tseng, Chien-Hua ^{[7
,8
]}

Chen, Hsuan-Yu ^{[9
,10
,11
]}

Chen, Kun-Chieh ^{[3
]}

Tsai, Chi-Ren ^{[12
,13
]}

Yang, Cheng-Ta ^{[5
,14
]}

Yu, Sung-Liang ^{[15
,16
,17
,18
,19
,20
]}

Su, Kang-Yi ^{[15
,16
]}

Yu, Chong-Jen ^{[21
,22
]}

Ho, Chao-Chi ^{[21
,22
]}

Hsia, Te-Chun ^{[23
,24
]}

Wu, Ming-Fang ^{[25
,26
,27
]}

Chiu, Kuo-Liang ^{[28
,29
]}

Liu, Chien-Ming ^{[28
]}

Yang, Pan-Chyr ^{[21
,22
]}

Chen, Jeremy J. W. ^{[1
]}

Chang, Gee-Chen ^{[1
,3
,4
]}

机构：

[1] Natl Chung Hsing Univ, Inst Biomed Sci, Taichung, Taiwan

[2] Taichung Vet Gen Hosp, Dept Internal Med, Div Crit Care & Resp Therapy, Taichung, Taiwan

[3] Taichung Vet Gen Hosp, Dept Internal Med, Div Chest Med, Taichung, Taiwan

[4] Natl Yang Ming Univ, Fac Med, Sch Med, Taipei, Taiwan

[5] Chang Gung Mem Hosp, Dept Thorac Med, Taoyuan, Taiwan

[6] Chang Gung Univ, Coll Med, Taoyuan, Taiwan

[7] Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Taipei, Taiwan

[8] Taichung Vet Gen Hosp, Dept Crit Care Med, Taichung, Taiwan

[9] Acad Sinica, Inst Stat Sci, Taipei, Taiwan

[10] Natl Taiwan Univ, Coll Med, Taipei, Taiwan

[11] Natl Taiwan Univ, Coll Life Sci, Taipei, Taiwan

[12] Taichung Vet Gen Hosp, Dept Pediat, Taichung, Taiwan

[13] Natl Chung Hsing Univ, Inst Mol Biol, Taichung, Taiwan

[14] Chang Gung Univ, Coll Med, Dept Resp Therapy, Taoyuan, Taiwan

[15] Natl Taiwan Univ, Coll Med, Dept Clin Lab Sci & Med Biotechnol, Taipei, Taiwan

[16] Natl Taiwan Univ Hosp, Dept Lab Med, Taipei, Taiwan

[17] Natl Taiwan Univ, Ctr Genom Med, Taipei, Taiwan

[18] Natl Taiwan Univ, Coll Med, Dept Pathol, Taipei, Taiwan

[19] Natl Taiwan Univ, Coll Med, Grad Inst Pathol, Taipei, Taiwan

[20] Natl Taiwan Univ, Coll Med, Ctr Optoelect Biomed, Taipei, Taiwan

[21] Natl Taiwan Univ Hosp, Dept Internal Med, Div Pulm Med, Taipei, Taiwan

[22] Natl Taiwan Univ, Coll Med, Taipei, Taiwan

[23] China Med Univ Hosp, Dept Internal Med, Taichung, Taiwan

[24] China Med Univ, Dept Resp Therapy, Taichung, Taiwan

[25] Chung Shan Med Univ Hosp, Dept Internal Med, Div Med Oncol, Taichung, Taiwan

[26] Chung Shan Med Univ Hosp, Dept Internal Med, Div Pulm Med, Taichung, Taiwan

[27] Chung Shan Med Univ, Sch Med, Taichung, Taiwan

[28] Taichung Tzu Chi Hosp, Dept Internal Med, Div Chest Med, Taichung, Taiwan

[29] Tzu Chi Univ, Sch Postbaccalaureate Chinese Med, Hualien, Taiwan

来源：

ONCOTARGET | 2016年 / 7卷 / 33期

关键词：

familial lung cancer; epidermal growth factor receptor (EGFR); non-small cell lung cancer; YAP1; FACTOR RECEPTOR GENE; QUALITY-OF-LIFE; NEVER-SMOKERS; PHASE-III; RISK; ADENOCARCINOMA; HISTORY; ASSOCIATION; INHIBITOR; ERLOTINIB;

D O I：

10.18632/oncotarget.10715

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite the advancement of epidermal growth factor receptor (EGFR) inhibitors in lung cancer therapy, it remains unclear whether EGFR mutation status in familial lung cancers is different from that of sporadic cases. In this multicenter retrospective study, we compared both the EGFR mutation frequency and patterns between familial and sporadic cases. The results explored that family history of lung cancer is an independent predictor for higher EGFR mutation rate in 1713 lung adenocarcinoma patients (Odd ratio 1.68, 95% CI 1.06-2.67, P = 0.028). However, the distribution of EGFR mutation subtypes was similar to that of sporadic cases. Part of our study involved 40 lung cancer families with at least 2 tumor tissues available within each single family (n = 88) and there was no familial aggregation pattern in EGFR mutation subtypes. There were two families harboring the YAP1 R331W germline risk allele and EGFR mutation statuses among YAP1 family members also varied. These phenomena may hint at the direction of future research into lung carcinogenesis and EGFR mutagenesis.

引用

页码：53299 / 53308

页数：10

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