The Role of Inflammation in Tinnitus: A Systematic Review and Meta-Analysis

被引：23
作者：
Mennink, Lilian M. [1 ,2 ,3 ]
Aalbers, Marlien W. [1 ,3 ]
van Dijk, Pim [2 ,3 ]
van Dijk, J. Marc C. [1 ,3 ]
机构：
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Neurosurg, NL-9713 GZ Groningen, Netherlands
[2] Univ Groningen, Univ Med Ctr Groningen, Dept Otorhinolaryngol Head & Neck Surg, NL-9713 GZ Groningen, Netherlands
[3] Univ Groningen, Univ Med Ctr Groningen, Res Sch Behav & Cognit Neurosci BCN, NL-9713 AV Groningen, Netherlands
来源：
JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 04期
关键词：
tinnitus; inflammation; microglia; astrocytes; cytokines; platelets; NECROSIS-FACTOR-ALPHA; MEAN PLATELET VOLUME; TO-LYMPHOCYTE RATIO; INTERLEUKIN-1 RECEPTOR ANTAGONIST; SALICYLATE-INDUCED TINNITUS; AUDITORY-CORTEX; CONDUCTING METAANALYSES; COCHLEAR NUCLEUS; IN-VIVO; EXPRESSION;
D O I：
10.3390/jcm11041000
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Subjective tinnitus is the perception of sound without the presence of an external source. Increasing evidence suggests that tinnitus is associated with inflammation. In this systematic review, the role of inflammation in subjective tinnitus was studied. Nine animal and twenty human studies reporting inflammatory markers in both humans and animals with tinnitus were included. It was established that TNF-alpha and IL-1 beta are increased in tinnitus, and that microglia and astrocytes are activated as well. Moreover, platelet activation may also play a role in tinnitus. In addition, we elaborate on mechanisms of inflammation in tinnitus, and discuss potential treatment options targeting inflammatory pathways.
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页数：24
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