Peroxisome Proliferator-Activated Receptors and Atherosclerosis

被引：30

作者：

Soskic, Sanja S. ^{[1
]}

Dobutovic, Branislava D. ^{[1
]}

Sudar, Emina M. ^{[1
]}

Obradovic, Milan M. ^{[1
]}

Nikolic, Dragana M. ^{[1
]}

Zaric, Bozidarka L. ^{[2
]}

Stojanovic, Srdan D. ^{[2
]}

Stokic, Edita J. ^{[3
]}

Mikhailidis, Dimitri P. ^{[4
]}

Isenovic, Esma R. ^{[1
]}

机构：

[1] Univ Belgrade, Inst Vinca, Lab Radiobiol & Mol Genet, Belgrade 11000, Serbia

[2] Univ Belgrade, Dept Chem, ICTM, Belgrade 11000, Serbia

[3] Inst Internal Med, Dept Endocrinol Diabet & Metab Disorders, Novi Sad, Serbia

[4] UCL, Sch Med, Dept Clin Biochem, Vasc Dis Prevent Clin, London W1N 8AA, England

来源：

ANGIOLOGY | 2011年 / 62卷 / 07期

关键词：

peroxisome proliferator-activated receptors alpha; atherosclerosis; peroxisome proliferator-activated receptors gamma; atherosclerotic plaque; TYPE-2; DIABETES-MELLITUS; SMOOTH-MUSCLE-CELLS; CORONARY STENT IMPLANTATION; INTIMA-MEDIA THICKNESS; PPAR-GAMMA ACTIVATION; IMPROVES ENDOTHELIAL FUNCTION; ALPHA AGONIST FENOFIBRATE; TISSUE FACTOR EXPRESSION; ARTERIAL-WALL THICKNESS; FATTY-ACIDS;

D O I：

10.1177/0003319711401012

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPAR alpha, -gamma, and -delta/beta, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, which might present new approaches involved in the antiatherosclerotic effects revealed in this review. In addition, in this review we are presenting latest data from recent performed clinical studies which have focus on novel approach to PPARs agonists as potential therapeutic agents in the treatment of complex disease such as atherosclerosis.

引用

页码：523 / 534

页数：12

共 150 条

[1]

ACHMAD TH, 1992, BIOCHEM BIOPH RES CO, V189, P994

[2] Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site [J].

Adams, M ;

Reginato, MJ ;

Shao, DL ;

Lazar, MA ;

Chatterjee, VK .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (08) :5128-5132

[3] The hinge-helix 1 region of peroxisome proliferator-activated receptor γ1 (PPARγ1) mediates interaction with extracellular signal-regulated kinase 5 and PPARγ1 transcriptional activation:: Involvement in flow-induced PPARγ activation in endothelial cells [J].

Akaike, M ;

Che, WY ;

Marmarosh, NL ;

Ohta, S ;

Osawa, M ;

Ding, B ;

Berk, BC ;

Yan, C ;

Abe, J .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (19) :8691-8704

[4] Conditional disruption of the peroxisome proliferator-activated receptor γ gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux [J].

Akiyama, TE ;

Sakai, S ;

Lambert, G ;

Nicol, CJ ;

Matsusue, K ;

Pimprale, S ;

Lee, YH ;

Ricote, M ;

Glass, CK ;

Brewer, HB ;

Gonzalez, FJ .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (08) :2607-2619

[5] Conditional knockout of macrophage PPARγ increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice [J].

Babaev, VR ;

Yancey, PG ;

Ryzhov, SV ;

Kon, V ;

Breyer, MD ;

Magnuson, MA ;

Fazio, S ;

Linton, MF .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (08) :1647-1653

[6] PPAR-RXR HETERODIMER ACTIVATES A PEROXISOME PROLIFERATOR RESPONSE ELEMENT UPSTREAM OF THE BIFUNCTIONAL ENZYME GENE [J].

BARDOT, O ;

ALDRIDGE, TC ;

LATRUFFE, N ;

GREEN, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 192 (01) :37-45

[7] p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor α -: A potential role in the cardiac metabolic stress response [J].

Barger, PM ;

Browning, AC ;

Garner, AN ;

Kelly, DP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (48) :44495-44501

[8] The mechanisms of action of PPARs [J].

Berger, J ;

Moller, DE .

ANNUAL REVIEW OF MEDICINE, 2002, 53 :409-435

[9] Risk of Fractures with Glitazones A Critical Review of the Evidence to Date [J].

Bodmer, Michael ;

Meier, Christian ;

Kraenzlin, Marius E. ;

Meier, Christoph R. .

DRUG SAFETY, 2009, 32 (07) :539-547

[10] PPARγ activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties [J].

Bouhlel, M. Amine ;

Derudas, Bruno ;

Rigamonti, Elena ;

Dievart, Rebecca ;

Brozek, John ;

Haulon, Stephan ;

Zawadzki, Christophe ;

Jude, Brigitte ;

Torpier, Gerard ;

Marx, Nikolaus ;

Staels, Bart ;

Chinetti-Gbaguidi, Giulia .

CELL METABOLISM, 2007, 6 (02) :137-143

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