Safety and efficacy of zotarolimus- eluting stents in the treatment of diabetic coronary lesions in Chinese patients: The RESOLUTE- DIABETES CHINA Study

被引：1

作者：

Zhu, Zhengbin ^{[1
,2
]}

Wu, Yongjian ^{[3
]}

Shen, Zhujun ^{[4
]}

Xu, Yawei ^{[5
]}

Li, Yigang ^{[6
]}

Wang, Yan ^{[7
]}

Su, Xi ^{[8
]}

Li, Bao ^{[9
]}

Jiang, Tiemin ^{[10
]}

Jiang, Jinfa ^{[11
]}

Wang, Lefeng ^{[12
]}

He, Shenghu ^{[13
]}

Li, Xueqi ^{[14
]}

Li, Hongwei ^{[15
]}

Liu, Yin ^{[16
]}

Zhou, Yujie ^{[17
]}

Tang, Qiang ^{[18
]}

Chen, Yundai ^{[19
]}

Fang, Weiyi ^{[20
]}

Jiang, Li ^{[21
]}

Lu, Chengzhi ^{[22
]}

Guo, Jincheng ^{[23
]}

Zhang, Jianjun ^{[24
]}

Chen, Shaoliang ^{[25
]}

Xia, Yong ^{[26
]}

Zheng, Hongchao ^{[27
]}

Wang, Bin ^{[28
]}

Zhang, Daifu ^{[29
]}

Feng, Liuliu ^{[30
]}

Tang, Lijiang ^{[31
]}

Xu, Peng ^{[32
]}

Liu, Xuebo ^{[33
]}

Zhang, Ruiyan ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Cardiol, 197 Rui Jin Er Rd,3rd Floor,12th Bldg, Shanghai 200025, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Cardiovasc Res Inst, Dept Cardiol, Shanghai, Peoples R China

[3] Chinese Acad Med Sci, Fuwai Hosp, Dept Cardiol, Beijing, Peoples R China

[4] Peking Union Med Coll Hosp, Dept Cardiol, Beijing, Peoples R China

[5] Shanghai Tenth Peoples Hosp, Dept Cardiol, Shanghai, Peoples R China

[6] Shanghai Jiao Tong Univ, Sch Med, Xin Hua Hosp, Dept Cardiol, Shanghai, Peoples R China

[7] Xiamen Univ, Xiamen Cardiovasc Hosp, Dept Cardiol, Fuzhou, Fujian, Peoples R China

[8] Wuhan Asia Heart Hosp, Dept Cardiol, Wuhan, Hubei, Peoples R China

[9] Shanxi Cardiovasc Hosp, Dept Cardiol, Xian, Shaanxi, Peoples R China

[10] Armed Police Logist Coll, Affiliated Hosp, Dept Cardiol, Tianjin, Peoples R China

[11] Shanghai Tongji Hosp, Dept Cardiol, Shanghai, Peoples R China

[12] Beijing Chao Yang Hosp, Dept Cardiol, Beijing, Peoples R China

[13] Northern Jiangsu Peoples Hosp, Dept Cardiol, Yangzhou, Jiangsu, Peoples R China

[14] Harbin Med Univ, Affiliated Hosp 4, Dept Cardiol, Harbin, Heilongjiang, Peoples R China

[15] Capital Med Univ, Beijing Friendship Hosp, Dept Cardiol, Beijing, Peoples R China

[16] Tianjin Chest Hosp, Dept Cardiol, Tianjin, Peoples R China

[17] Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing, Peoples R China

[18] Peking Univ, Shougang Hosp, Dept Cardiol, Beijing, Peoples R China

[19] Beijing PLA, Mil Gen Hosp, Dept Cardiol, Beijing, Peoples R China

[20] Shanghai Jiao Tong Univ, Sch Med, Shanghai Chest Hosp, Dept Cardiol, Shanghai, Peoples R China

[21] Shanghai Jiaotong Univ Med, Tong Ren Hosp, Dept Cardiol, Shanghai, Peoples R China

[22] Tianjin First Ctr Hosp, Dept Cardiol, Tianjin, Peoples R China

[23] Capital Med Univ, Beijing Luhe Hosp, Dept Cardiol, Beijing, Peoples R China

[24] Shanghai Pudong New Area Gongli Hosp, Dept Cardiol, Shanghai, Peoples R China

[25] Nanjing Med Univ, Nanjing Hosp 1, Dept Cardiol, Nanjing, Jiangsu, Peoples R China

[26] Xuzhou Med Univ, Affiiliated Hosp, Dept Cardiol, Xuzhou, Jiangsu, Peoples R China

[27] Shanghai Xuhui Cent Hosp, Dept Cardiol, Shanghai, Peoples R China

[28] Aerosp Ctr Hosp, Dept Cardiol, Beijing, Peoples R China

[29] Pudong New Area Peoples Hosp, Dept Cardiol, Shanghai, Peoples R China

[30] Shidong Hosp Shanghai Yangpu Dist, Dept Cardiol, Shanghai, Peoples R China

[31] Zhejiang Hosp, Dept Cardiol, Hangzhou, Zhejiang, Peoples R China

[32] Fudan Univ, Peoples Hosp Shanghai 5, Dept Cardiol, Shanghai, Peoples R China

[33] Tongji Univ, Sch Med, Shanghai East Hosp, Dept Cardiol, Shanghai, Peoples R China

来源：

JOURNAL OF DIABETES | 2019年 / 11卷 / 03期

关键词：

coronary artery disease; diabetes; percutaneous coronary intervention; revascularization; stent thrombosis; ARTERY-DISEASE; NEOINTIMAL HYPERPLASIA; MYOCARDIAL-INFARCTION; SIROLIMUS; OUTCOMES; INTERVENTION; EVEROLIMUS; MELLITUS; IMPLANTATION; ANGIOGRAPHY;

D O I：

10.1111/1753-0407.12832

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundThe RESOLUTE-DIABETES CHINA study was specifically designed to investigate the safety and efficacy of Resolute zotarolimus-eluting stents (ZES; Medtronic, Santa Rosa, CA, USA) in the treatment of diabetic coronary lesions in the Chinese population. MethodsIn all, 945 patients with de novo native coronary lesions and type 2 diabetes mellitus were recruited at 32 cardiac centers across the Chinese mainland and were implanted with Resolute ZES. The primary endpoint was target vessel failure (TVF); secondary endpoints were clinical outcomes, namely all-cause death, stroke, bleeding, target lesion revascularization (TLR), target vessel revascularization (TVR), non-TVR, and stent thrombosis (ST). The follow-up period for all endpoints was 12months after the procedure. ResultsIn all, 933 patients (98.73%) had clinical follow-up at 12months. The rate of TVF was 11.60%, whereas the rate of occurrence of secondary endpoints was 5.47%, with four patients (0.43%) having subacute or late ST. There were no significant differences in TVF rates comparing patients with different HbA1c levels or receiving different glucose control treatments (all P>0.05). Patients with multivessel lesions had higher TVF rates (95% confidence intervals) than those with single-vessel lesions (16.76% [12.10%-22.97%) vs 9.72% [7.79%-12.11%], respectively; P= 0.006). There were no significant differences in TVF rates in patients with or without small vessels, bifurcated lesions, or chronic total occlusions (all P>0.05). [Correction added on 17 January 2019, after first online publication: in the second sentence of Results section, TLF was changed to TVF.]. ConclusionsResolute ZES may perform well in the Chinese diabetic population, especially in those with poor glucose control, complex lesions, and certain unfavorable clinical features. Further studies are needed to determine why ZES perform well in this population.

引用

页码：204 / 213

页数：10

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