Physical and Psychological Predictors of Quality of Life in Chinese Colorectal Cancer Patients During Chemotherapy

被引:31
作者
Zhang, Meifen [1 ]
Peng, Lifen [2 ]
Liu, Weiyan [3 ]
Wen, Yongshan [4 ]
Wu, Xiaodan [4 ]
Zheng, Meichun [4 ]
Zhu, Yaping [4 ]
Liu, Qianwen [4 ]
Chan, Sally [5 ]
机构
[1] Sun Yat Sen Univ, Sch Nursing, Guangzhou 510275, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Dept Nursing, Affiliated Hosp 1, Guangzhou 510275, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Dept Nursing, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, Dept Nursing, Ctr Canc, Guangzhou 510275, Guangdong, Peoples R China
[5] Univ Newcastle, Sch Nursing & Midwifery, Callaghan, NSW 2308, Australia
关键词
Anxiety; Chinese patient; Colorectal cancer; Depression; Quality of life; Self-efficacy; Symptom distress; ANDERSON-SYMPTOM-INVENTORY; FUNCTIONAL ASSESSMENT; DEPRESSION; ANXIETY; SURVIVORS; VALIDATION; HEALTH; TRAJECTORIES; POPULATION; PEOPLE;
D O I
10.1097/NCC.0000000000000190
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Maintaining quality of life (QOL) during chemotherapy is a critical aspect of cancer treatment. Instruments have been developed to assess symptom distress, self-efficacy, anxiety, depression, and other factors impacting QOL during cancer treatment, but Chinese versions have become available only recently. Objective: The aim of this study was to identify factors predictive of QOL during chemotherapy in Chinese colorectal cancer (CRC) patients. Methods: Patients completed Chinese versions of the Hospital Anxiety and Depression Scale, MD Anderson Symptom Inventory (a measure of symptom distress), Stanford Inventory of Cancer Patient Adjustment (a measure of self-efficacy), and Functional Assessment of Cancer Treatment-General (a measure of QOL) before and after 3 and 6 months of chemotherapy. Results: Of 152 consecutive CRC patients (men/women, 98/54; mean age, 53.3 11.3 years, 25-75 years; stage II/III, 59/93), 121 completed all questionnaires (79.6%). Self-efficacy dimensions communication, activity management, personal management, and affective management improved progressively over 6 months (all P < .05). Fatigue, nausea, lack of appetite, disturbed sleep, and vomiting peaked at 3 months and declined thereafter (P < .05). Patients who are younger than 60 years, are male, and with stage II CRC exhibited higher 3- and 6-month QOL scores (all P < .05). Multiple regression identified self-efficacy, anxiety, and symptom distress as independent predictors of QOL at 6 months. Conclusions: Enhanced self-efficacy, reduced symptom distress, and lower general anxiety would improve QOL during chemotherapy for CRC patients. Implications for Practice: These instruments can help identify CRC patients at risk of low QOL for additional psychotherapy or specific treatment modifications.
引用
收藏
页码:312 / 321
页数:10
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