Dipeptide Inhibitors as Potent Botulinum Neurotoxin Type A Light Chain Inhibitors

被引:0
|
作者
Amezcua, Martin [1 ]
Cruz, Ricardo S. [1 ]
Ku, Alex [1 ]
Moran, Wilfred [1 ]
Ortega, Marcos E. [2 ]
Salzameda, Nicholas T. [1 ]
机构
[1] Calif State Univ Fullerton, Dept Chem & Biochem, Fullerton, CA 92634 USA
[2] Texas Tech Univ, Woody L Hunt Sch Dent Med, El Paso, TX USA
关键词
Botulinum neurotoxin light chain; Drug discovery; Enzyme assay; Peptides; Small molecule inhibitors; X-ray crystallography;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:S4 / S4
页数:1
相关论文
共 50 条
  • [21] Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: Synthesis, crystallography, modeling, kinetic and cellular based studies
    Silhar, Peter
    Silvaggi, Nicholas R.
    Pellett, Sabine
    Capkova, Katerina
    Johnson, Eric A.
    Allen, Karen N.
    Janda, Kim D.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (05) : 1344 - 1348
  • [22] An Integrated Pharmacophore/Docking/3D-QSAR Approach to Screening a Large Library of Products in Search of Future Botulinum Neurotoxin A Inhibitors
    Gentile, Davide
    Floresta, Giuseppe
    Patamia, Vincenzo
    Chiaramonte, Rita
    Mauro, Giulia Letizia
    Rescifina, Antonio
    Vecchio, Michele
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (24) : 1 - 18
  • [23] Chirality Holds the Key for Potent Inhibition of the Botulinum Neurotoxin Serotype A Protease
    Stowe, G. Neil
    Silhar, Peter
    Hixon, Mark S.
    Silvaggi, Nicholas R.
    Allen, Karen N.
    Moe, Scott T.
    Jacobson, Alan R.
    Barbieri, Joseph T.
    Janda, Kim D.
    ORGANIC LETTERS, 2010, 12 (04) : 756 - 759
  • [24] Structural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening
    Hu, Xin
    Legler, Patricia M.
    Southall, Noel
    Maloney, David J.
    Simeonov, Anton
    Jadhav, Ajit
    JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2014, 28 (07) : 765 - 778
  • [25] Peptide inhibitors of botulinum neurotoxin serotype A: design, inhibition, cocrystal structures, structure-activity relationship and pharmacophore modeling
    Kumar, Gyanendra
    Kumaran, Desigan
    Ahmed, S. Ashraf
    Swaminathan, Subramanyam
    ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2012, 68 : 511 - 520
  • [26] Newly Designed Quinolinol Inhibitors Mitigate the Effects of Botulinum Neurotoxin A in Enzymatic, Cell-Based, and ex Vivo Assays
    Bremer, Paul T.
    Adler, Michael
    Phung, Cecilia H.
    Singh, Ajay K.
    Janda, Kim D.
    JOURNAL OF MEDICINAL CHEMISTRY, 2017, 60 (01) : 338 - 348
  • [27] Potent Triazolopyridine Myeloperoxidase Inhibitors
    Wurtz, Nicholas R.
    Viet, Andrew
    Shaw, Scott A.
    Dilger, Andrew
    Valente, Meriah N.
    Khan, Javed A.
    Jusuf, Sutjano
    Narayanan, Rangaraj
    Fernando, Gayani
    Lo, Fred
    Liu, Xiaoqin
    Locke, Gregory A.
    Kopcho, Lisa
    Abell, Lynn M.
    Sleph, Paul
    Basso, Michael
    Zhao, Lei
    Wexler, Ruth R.
    Duclos, Franck
    Kick, Ellen K.
    ACS MEDICINAL CHEMISTRY LETTERS, 2018, 9 (12): : 1175 - 1180
  • [28] HTS by NMR for the Identification of Potent and Selective Inhibitors of Metalloenzymes
    Baggio, Carlo
    Cerofolini, Linda
    Fragai, Marco
    Luchinat, Claudio
    Pellecchia, Maurizio
    ACS MEDICINAL CHEMISTRY LETTERS, 2018, 9 (02): : 137 - 142
  • [29] Discovery of a Potent Botulinum Neurotoxin A Inhibitor ZM299 with Effective Protections in Botulism Mice
    Wang, Jianxin
    Wu, Yuelin
    Luo, Deyan
    Zhuang, Chunlin
    Ning, Nianzhi
    Zhang, Yanming
    He, Zhili
    Gao, Jie
    Hong, Zhanying
    Xv, Xiguo
    Zhang, Wannian
    Li, Tao
    Miao, Zhenyuan
    Wang, Hui
    CHINESE JOURNAL OF CHEMISTRY, 2022, 40 (03): : 357 - 364
  • [30] Dipeptide Inhibitors of Thermolysin and Angiotensin I-Converting Enzyme
    Khan, Mahmud Tareq Hassan
    Dedachi, Kenichi
    Matsui, Toshiro
    Kurita, Noriyuki
    Borgatti, Monica
    Gambari, Roberto
    Sylte, Ingebrigt
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2012, 12 (16) : 1748 - 1762