Stimuli-Responsive Drug Delivery Systems for the Diagnosis and Therapy of Lung Cancer

被引：15

作者：

Lin, Xu ^{[1
]}

Wu, Jiahe ^{[2
]}

Liu, Yupeng ^{[2
]}

Lin, Nengming ^{[2
,3
]}

Hu, Jian ^{[1
]}

Zhang, Bo ^{[2
,3
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 1, Dept Thorac Surg, Sch Med, Hangzhou 310003, Peoples R China

[2] Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Sch Med, Key Lab Clin Canc Pharmacol & Toxicol Res Zhejian, Hangzhou 310003, Peoples R China

[3] Zhejiang Univ, Canc Ctr, Hangzhou 310003, Peoples R China

来源：

MOLECULES | 2022年 / 27卷 / 03期

关键词：

stimuli-responsive; drug delivery; lung cancer; CHEMO-PHOTOTHERMAL THERAPY; NANOPARTICLES; NANOCARRIERS; PENETRATION; RELEASE; DENDRIMERS; INHIBITOR; PRODRUG;

D O I：

10.3390/molecules27030948

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer death worldwide. Numerous drugs have been developed to treat lung cancer patients in recent years, whereas most of these drugs have undesirable adverse effects due to nonspecific distribution in the body. To address this problem, stimuli-responsive drug delivery systems are imparted with unique characteristics and specifically deliver loaded drugs at lung cancer tissues on the basis of internal tumor microenvironment or external stimuli. This review summarized recent studies focusing on the smart carriers that could respond to light, ultrasound, pH, or enzyme, and provided a promising strategy for lung cancer therapy.

引用

页数：14

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