Mucosal permeability and mast cells as targets for functional gastrointestinal disorders

被引：33

作者：

Keita, Asa V. ^{[1
]}

Soderholm, Johan D. ^{[1
,2
]}

机构：

[1] Linkoping Univ, Div Surg Orthoped & Oncol, Dept Clin & Expt Med, Linkoping, Sweden

[2] Cty Council Ostergotland, Dept Surg, Linkoping, Sweden

来源：

CURRENT OPINION IN PHARMACOLOGY | 2018年 / 43卷

基金：

瑞典研究理事会;

关键词：

IRRITABLE-BOWEL-SYNDROME; VASOACTIVE INTESTINAL POLYPEPTIDE; DILATED INTERCELLULAR SPACES; EPITHELIAL BARRIER; ABDOMINAL-PAIN; IMMUNE ACTIVATION; REFLUX DISEASE; COLONIC-MUCOSA; STRESS; MICROBIOTA;

D O I：

10.1016/j.coph.2018.08.011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The intestinal mucosa is constantly exposed to harmful lumina! content, and uptake is closely controlled and regulated by neuro-immune factors. If control is broken, it might lead to ongoing enhanced mucosal permeability, potentially resulting in functional gastrointestinal disorders. The importance of mast cells in the regulation of the mucosal barrier has become obvious, and increased numbers and more activated mast cells have been observed in irritable bowel syndrome, functional dyspepsia and gastroesophageal reflux disease. To target the disturbed mucosal permeability, directly or via mast cells, is therefore currently of major interest. For example, administration of mast cell stabilizers and probiotics have shown promising effects in patients with functional gastrointestinal disorders.

引用

页码：66 / 71

页数：6

共 72 条

[1] Luminal Cysteine-Proteases Degrade Colonic Tight Junction Structure and Are Responsible for Abdominal Pain in Constipation-Predominant IBS [J].

Annahazi, Anita ;

Ferrier, Laurent ;

Bezirard, Valerie ;

Leveque, Mathilde ;

Eutamene, Helene ;

Ait-Belgnaoui, Afifa ;

Coeffier, Moise ;

Ducrotte, Philippe ;

Roka, Richard ;

Inczefi, Orsolya ;

Gecse, Krisztina ;

Rosztoczy, Andras ;

Molnar, Tamas ;

Ringel-Kulka, Tamar ;

Ringel, Yehuda ;

Piche, Thierry ;

Theodorou, Vassilia ;

Wittmann, Tibor ;

Bueno, Lionel .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2013, 108 (08) :1322-1331

[2] Frontline Science: Corticotropin-releasing factor receptor subtype 1 is a critical modulator of mast cell degranulation and stress-induced pathophysiology [J].

Ayyadurai, Saravanan ;

Gibson, Amelia J. ;

D'Costa, Susan ;

Overman, Elizabeth L. ;

Sommerville, Laura J. ;

Poopal, Ashwini C. ;

Mackey, Emily ;

Li, Yihang ;

Moeser, Adam J. .

JOURNAL OF LEUKOCYTE BIOLOGY, 2017, 102 (06) :1299-1312

[3] Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome [J].

Barbara, G ;

Stanghellini, V ;

De Giorgio, R ;

Cremon, C ;

Cottrell, GS ;

Santini, D ;

Pasquinelli, G ;

Morselli-Labate, AM ;

Grady, EF ;

Bunnett, NW ;

Collins, SM ;

Corinalidesi, R .

GASTROENTEROLOGY, 2004, 126 (03) :693-702

[4] New insights in the etiology and pathophysiology of irritable bowel syndrome: Contribution of neonatal stress models [J].

Barreau, Frederick ;

Ferrier, Laurent ;

Fioramonti, Jean ;

Bueno, Lionel .

PEDIATRIC RESEARCH, 2007, 62 (03) :240-245

[5] Vasoactive Intestinal Polypeptide and Mast Cells Regulate Increased Passage of Colonic Bacteria in Patients With Irritable Bowel Syndrome [J].

Bednarska, Olga ;

Walter, Susanna A. ;

Casado-Bedmar, Maite ;

Strom, Magnus ;

Salvo-Romero, Eloisa ;

Vicario, Maria ;

Mayer, Emeran A. ;

Keita, Asa V. .

GASTROENTEROLOGY, 2017, 153 (04) :948-+

[6] The Expression and the Cellular Distribution of the Tight Junction Proteins Are Altered in Irritable Bowel Syndrome Patients With Differences According to the Disease Subtype [J].

Bertiaux-Vandaele, Nathalie ;

Youmba, Stephanie Beutheu ;

Belmonte, Liliana ;

Lecleire, Stephane ;

Antonietti, Michel ;

Gourcerol, Guillaume ;

Leroi, Anne-Marie ;

Dechelotte, Pierre ;

Menard, Jean-Francois ;

Ducrotte, Philippe ;

Coeffier, Moise .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2011, 106 (12) :2165-2173

[7] Glutamine Restores Tight Junction Protein Claudin-1 Expression in Colonic Mucosa of Patients With Diarrhea-Predominant Irritable Bowel Syndrome [J].

Bertrand, Julien ;

Ghouzali, Ibtissem ;

Guerin, Charlene ;

Bole-Feysot, Christine ;

Gouteux, Melodie ;

Dechelotte, Pierre ;

Ducrotte, Philippe ;

Coeffier, Moise .

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 2016, 40 (08) :1170-1176

[8] THE ROLE OF MAST-CELLS IN INFLAMMATORY PROCESSES - EVIDENCE FOR NERVE MAST-CELL INTERACTIONS [J].

BIENENSTOCK, J ;

TOMIOKA, M ;

MATSUDA, H ;

STEAD, RH ;

QUINONEZ, G ;

SIMON, GT ;

COUGHLIN, MD ;

DENBURG, JA .

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1987, 82 (3-4) :238-243

[9] Physiological and pathophysiological functions of intestinal mast cells [J].

Bischoff, Stephan C. .

SEMINARS IN IMMUNOPATHOLOGY, 2009, 31 (02) :185-205

[10] Neuroimmune factors in functional gastrointestinal disorders: A focus on irritable bowel syndrome [J].

Boeckxstaens, G. E. ;

Wouters, M. M. .

NEUROGASTROENTEROLOGY AND MOTILITY, 2017, 29 (06)

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