Physiology of Parathyroid Hormone

被引：83
|
作者：
Goltzman, David [1 ,2 ,3 ,4 ]
机构：
[1] McGill Univ, Dept Med, Hlth Ctr, 1001 Decarie Blvd, Montreal, PQ H4A 3J1, Canada
[2] McGill Univ, Res Inst, Hlth Ctr, 1001 Decarie Blvd, Montreal, PQ H4A 3J1, Canada
[3] McGill Univ, Dept Med, 845 Sherbrooke St West, Montreal, PQ H3A 0B9, Canada
[4] McGill Univ, Dept Physiol, 845 Sherbrooke St West, Montreal, PQ H3A 0B9, Canada
来源：
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2018年 / 47卷 / 04期
关键词：
Parathyroid hormone; Calcium; Phosphate; Bone turnover; Anabolic actions; Catabolic actions; (PTH)/PTH-RELATED PEPTIDE RECEPTOR; CALCIUM-SENSING RECEPTOR; NUCLEAR-LOCALIZATION SEQUENCE; COTRANSPORTER NAPI-IIA; OSTEOBLAST-LIKE CELLS; BONE-MINERAL DENSITY; OSTEOCLAST DIFFERENTIATION; POSTMENOPAUSAL WOMEN; PROXIMAL TUBULE; GENE-EXPRESSION;
D O I：
10.1016/j.ecl.2018.07.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Parathyroid hormone (PTH) is the major secretory product of the parathyroid glands, and in hypocalcemic conditions, can enhance renal calcium reabsorption, increase active vitamin D production to increase intestinal calcium absorption, and mobilize calcium from bone by increasing turnover, mainly but not exclusively in cortical bone. PTH has therefore found clinical use as replacement therapy in hypoparathyroidism. PTH also may have a physiologic role in augmenting bone formation, particularly in trabecular and to some extent in cortical bone. This action has been applied to the clinic to provide anabolic therapy for osteoporosis.
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页码：743 / +
页数：17
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