Sulindac suppresses tumorigenesis in the Min mouse

被引：167

作者：

BeazerBarclay, Y

Levy, DB

Moser, AR

Dove, WF

Hamilton, SR

Vogelstein, B

Kinzler, KW

机构：

[1] JOHNS HOPKINS UNIV, SCH MED, CTR ONCOL, BALTIMORE, MD 21231 USA

[2] JOHNS HOPKINS UNIV, SCH MED, DEPT PATHOL, BALTIMORE, MD 21231 USA

[3] JOHNS HOPKINS UNIV, SCH MED, HOWARD HUGHES MED INST, BALTIMORE, MD 21231 USA

[4] UNIV WISCONSIN, DEPT HUMAN ONCOL, MADISON, WI 53792 USA

[5] UNIV WISCONSIN, MCARDLE LAB CANC RES, MADISON, WI 53706 USA

来源：

CARCINOGENESIS | 1996年 / 17卷 / 08期

关键词：

D O I：

10.1093/carcin/17.8.1757

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Min mouse provides a genetically defined model for inherited and sporadic forms of human colorectal tumorigenesis. To test the suitability of this model for the evaluation and optimization of chemopreventive agents, we examined the effects of sulindac on tumorigenesis in Min mice as this compound can inhibit colorectal tumorigenesis in human familial adenomatous polyposis patients. Treatment of Min mice with sulindac in their drinking water (84 mg/l) or diet (167 and 334 p.p.m.) resulted in a significantly decreased average tumor load, The conservation of sulindac activity in the Min mouse provides an opportunity to explore the mechanism of sulindac suppression as well as to test other potential chemopreventive agents.

引用

页码：1757 / 1760

页数：4

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