Severe Hypercalcemia Associated with Hepatocellular Carcinoma Secreting Intact Parathyroid Hormone: A Case Report

被引：9

作者：

Abe, Yoko ^{[1
]}

Makiyama, Hiroaki ^{[1
]}

Fujita, Yomo ^{[1
]}

Tachibana, Yasuhiro ^{[1
]}

Kamada, Go ^{[1
]}

Uebayashi, Minoru ^{[1
]}

机构：

[1] Kitami Red Cross Hosp, Dept Gastroenterol & Hepatol, Kitami, Hokkaido, Japan

来源：

INTERNAL MEDICINE | 2011年 / 50卷 / 04期

关键词：

liver cancer; diagnosis; therapeutic chemoembolization; HUMORAL HYPERCALCEMIA; PEPTIDE; MALIGNANCY; EXPRESSION; RECEPTOR; GENE;

D O I：

10.2169/internalmedicine.50.4389

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Here we describe a 73-year-old woman with hypercalcemia caused by a hepatocellular carcinoma (HCC) secreting intact parathyroid hormone (iPTH). Serum tumor markers and dynamic CT findings indicated a diagnosis of HCC. The source of the elevated serum iPTH was not obvious. Transarterial chemoembolization (TACE) was effective against the HCC, and the serum iPTH level fell to within the normal range, suggesting a correlation between the carcinoma and the iPTH. About 2 months later, the tumor had grown and the serum calcium level increased leading to physical deterioration and death. This clinical course suggested that HCC can ectopically secrete iPTH.

引用

页码：329 / 333

页数：5

共 14 条

[1] Arterial blood supply of hepatocellular carcinoma and histologic grading: Radiologic-pathologic correlation [J].

Asayama, Yoshiki ;

Yoshimitsu, Kengo ;

Nishihara, Yunosuke ;

Irie, Hiroyuki ;

Aishima, Shinichi ;

Taketomi, Akinobu ;

Honda, Hiroshi .

AMERICAN JOURNAL OF ROENTGENOLOGY, 2008, 190 (01) :W28-W34

[2]

ATTALI P, 1984, DIGEST DIS SCI, V29, P446

[3]

Belli Susana Haydee, 2009, Acta Gastroenterol Latinoam, V39, P184

[4] Role of the calcium-sensing receptor in parathyroid gland physiology [J].

Chen, RA ;

Goodman, WG .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2004, 286 (06) :F1005-F1011

[5]

JUPPNER H, 1988, J BIOL CHEM, V263, P8557

[6] Intact PTH-producing hepatocellular carcinoma treated by transcatheter arterial embolization [J].

Koyama, Y ;

Ishijima, H ;

Ishibashi, A ;

Katsuya, T ;

Ishizaka, H ;

Aoki, J ;

Endo, K .

ABDOMINAL IMAGING, 1999, 24 (02) :144-146

[7]

Mahoney Eric J, 2006, Endocr Pract, V12, P302

[8] IDENTIFICATION OF A CDNA-ENCODING A PARATHYROID HORMONE-LIKE PEPTIDE FROM A HUMAN-TUMOR ASSOCIATED WITH HUMORAL HYPERCALCEMIA OF MALIGNANCY [J].

MANGIN, M ;

WEBB, AC ;

DREYER, BE ;

POSILLICO, JT ;

IKEDA, K ;

WEIR, EC ;

STEWART, AF ;

BANDER, NH ;

MILSTONE, L ;

BARTON, DE ;

FRANCKE, U ;

BROADUS, AE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (02) :597-601

[9] ISOLATION AND CHARACTERIZATION OF THE HUMAN PARATHYROID HORMONE-LIKE PEPTIDE GENE [J].

MANGIN, M ;

IKEDA, K ;

DREYER, BE ;

BROADUS, AE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (07) :2408-2412

[10]

OLDENBURG WA, 1982, ARCH SURG-CHICAGO, V117, P1363

← 1 2 →