Study of the Association of Polymorphisms of p53 and p21 with the Risk of Development of Stomach Cancer

被引：6

作者：

Dmitrieva, A. I. ^{[1
,2
]}

Serebryakova, V. A. ^{[1
,2
]}

Rakitin, S. S. ^{[1
]}

Kudyakov, L. A. ^{[2
]}

Novitskii, V. V. ^{[1
,3
]}

Yankovich, K. I. ^{[1
,2
]}

Sevostyanova, N. V. ^{[1
,3
]}

机构：

[1] Siberian State Med Univ, Minist Hlth Russian Federat, Tomsk, Russia

[2] Tomsk Reg Oncol Ctr, Tomsk, Russia

[3] Natl Res Tomsk State Univ, Tomsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2017年 / 164卷 / 01期

关键词：

p53; G215C; p21 A1026G and G369C; polymorphism; genes regulating cell cycle; stomach cancer; GASTRIC-CANCER;

D O I：

10.1007/s10517-017-3932-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A real-time PCR with hybridization and fluorescent detection was used to analyze the distribution of p53 G215C, p21A1026G, and G369C gene polymorphisms in patients with stomach cancer and healthy subjects. It was found that allele C, genotypes of CC and GC of G215C p53, and G369C p21 polymorphisms and allele A and AA and GA genotypes of A1026G p21 polymorphism are significantly associated with the risk of stomach cancer development.

引用

页码：95 / 98

页数：4

共 15 条

[1] p21 in cancer: intricate networks and multiple activities [J].

Abbas, Tarek ;

Dutta, Anindya .

NATURE REVIEWS CANCER, 2009, 9 (06) :400-414

[2] Alterations of the TP53 Gene in Gastric and Esophageal Carcinogenesis [J].

Bellini, Marilanda Ferreira ;

Targa Cadamuro, Aline Cristina ;

Succi, Maysa ;

Proenca, Marcela Alcantara ;

Silva, Ana Elizabete .

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2012,

[3]

Cañas M, 2009, INVEST CLIN, V50, P153

[4] A Novel Tri-Allelic Insertion/Deletion Polymorphism in the Promoter of p21Waf1Cip1 and the Association with Gastric Cancer [J].

Chen, Zhiqiang ;

Dong, Ying ;

Wang, Ningju ;

Liang, Hanmei ;

Du, Yong ;

Ye, Xiaofeng ;

Jia, Wei ;

He, Zhongyi ;

Jiang, Yideng ;

Yang, Yinxue ;

Yang, Wenjun .

GENETIC TESTING AND MOLECULAR BIOMARKERS, 2014, 18 (02) :112-116

[5]

Dmitrieva AI, 2015, TUBERKULEZ B LEGKHIK, V93, P50

[6] Arg72Pro TP53 polymorphism and cancer susceptibility: a comprehensive meta-analysis of 302 case-control studies [J].

Francisco, Guilherme ;

Menezes, Paulo Rossi ;

Eluf-Neto, Jose ;

Chammas, Roger .

INTERNATIONAL JOURNAL OF CANCER, 2011, 129 (04) :920-930

[7] Structure-function-rescue: the diverse nature of common p53 cancer mutants [J].

Joerger, A. C. ;

Fersht, A. R. .

ONCOGENE, 2007, 26 (15) :2226-2242

[8]

Ke-Xiang Z., 2011, MOL BIOL REP, V39, P723

[9]

Kuznetsova IA, 2012, SIB MED ZH IRKUTSK, V110, P47

[10] Resistance and gain-of-resistance phenotypes in cancers harboring wild-type p53 [J].

Martinez-Rivera, Michelle ;

Siddik, Zahid H. .

BIOCHEMICAL PHARMACOLOGY, 2012, 83 (08) :1049-1062

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