Chaotically Accelerated Polymerase Chain Reaction by Microscale Rayleigh-Benard Convection

被引：21

作者：

Muddu, Radha ^{[2
]}

Hassan, Yassin A. ^{[2
,3
]}

Ugaz, Victor M. ^{[1
]}

机构：

[1] Texas A&M Univ, Artie McFerrin Dept Chem Engn, College Stn, TX 77843 USA

[2] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA

[3] Texas A&M Univ, Dept Nucl Engn, College Stn, TX 77843 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 13期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

analytical methods; biochemistry; chaos; DNA replication; microreactors; NATURAL-CONVECTION;

D O I：

10.1002/anie.201004217

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Going with the flow: DNA replication by the polymerase chain reaction (PCR) can proceed at a greatly accelerated rate when performed in the presence of a chaotic flow induced by microscale thermal convection (see picture). The consequences of these effects sharply contradict established design rules for chemistry involving coupled flow and reaction. © 2011 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3048 / 3052

页数：5

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