Functional significance of histone deacetylase diversity

被引：327
作者：
Khochbin, S [1 ]
Verdel, A [1 ]
Lemercier, C [1 ]
Seigneurin-Berny, D [1 ]
机构：
[1] Inst Albert Bonniot, Fac Med, Lab Biol Mol & Cellulaire Differenciat, F-38706 Grenoble, France
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2001年 / 11卷 / 02期
关键词：
D O I：
10.1016/S0959-437X(00)00174-X
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Nucleocytoplasmic shuttling of histone deacetylases is emerging as a major step in determining the composition, and hence the activity, of the corresponding nuclear regulatory complexes. This shuffling process is one of the distinctive characteristics of these enzymes, themselves belonging to structurally and functionally different classes. Considering the specific features of each class of deacetylases, it is possible to determine how each member can contribute to particular cellular functions.
引用
收藏
页码：162 / 166
页数：5
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