Antiproliferative activity of chelating N,O- and N,N-ruthenium(II) arene functionalised poly(propyleneimine) dendrimer scaffolds

被引：146
作者：
Govender, Preshendren [1 ]
Renfrew, Anna K. [2 ]
Clavel, Catherine M. [2 ]
Dyson, Paul J. [2 ]
Therrien, Bruno [3 ]
Smith, Gregory S. [1 ]
机构：
[1] Univ Cape Town, Dept Chem, ZA-7701 Cape Town, South Africa
[2] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland
[3] Univ Neuchatel, Inst Chem, CH-2000 Neuchatel, Switzerland
来源：
DALTON TRANSACTIONS | 2011年 / 40卷 / 05期
基金：
英国医学研究理事会; 新加坡国家研究基金会;
关键词：
RUTHENIUM COMPLEXES; ANTICANCER ACTIVITY; MOLECULAR-STRUCTURE; CATALYTIC-ACTIVITY; RUTHENIUM(II)-ARENE COMPLEXES; NICKEL-CATALYSTS; METAL-COMPLEXES; ANTITUMOR DRUG; IN-VITRO; DNA;
D O I：
10.1039/c0dt00761g
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Chelating neutral (N,O) and cationic (N,N) first-and second-generation ruthenium(II) arene metallodendrimers based on poly(propyleneimine) dendrimer scaffolds were obtained from dinuclear arene ruthenium precursors by reactions with salicylaldimine and iminopyridyl dendritic ligands, respectively. The N, N cationic complexes were isolated as hexafluorophosphate salts and were characterised by NMR and IR spectroscopy, and MALDI-TOF mass spectrometry. Related mononuclear complexes were obtained in a similar manner and their molecular structures have been determined by X-ray diffraction analysis. The cytotoxicities of the mono-and multinuclear complexes were established using A2780 and A2780cisR human ovarian carcinoma cancer cell lines.
引用
收藏
页码：1158 / 1167
页数：10
相关论文
共 77 条
[61]   Combined arene ruthenium porphyrins as chemotherapeutics and photosensitizers for cancer therapy [J].
Schmitt, Frederic ;
Govindaswamy, Padavattan ;
Zava, Olivier ;
Suess-Fink, Georg ;
Juillerat-Jeanneret, Lucienne ;
Therrien, Bruno .
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2009, 14 (01) :101-109
[62]   Influence of hydrogen-bonding substituents on the cytotoxicity of RAPTA compounds [J].
Scolaro, C ;
Geldbach, TJ ;
Rochat, S ;
Dorcier, A ;
Gossens, C ;
Bergamo, A ;
Cocchietto, M ;
Tavernelli, I ;
Sava, G ;
Rothlisberger, U ;
Dyson, PJ .
ORGANOMETALLICS, 2006, 25 (03) :756-765
[63]   In vitro and in vivo evaluation of ruthenium(II)-arene PTA complexes [J].
Scolaro, C ;
Bergamo, A ;
Brescacin, L ;
Delfino, R ;
Cocchietto, M ;
Laurenczy, G ;
Geldbach, TJ ;
Sava, G ;
Dyson, PJ .
JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (12) :4161-4171
[64]   A short history of SHELX [J].
Sheldrick, George M. .
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2008, 64 :112-122
[65]   The synthesis and catalytic activity of a first-generation poly(propylene imine) pyridylimine palladium metallodendrimer [J].
Smith, G ;
Chen, R ;
Mapolie, S .
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2003, 673 (1-2) :111-115
[66]   Iminopyridyl-palladium dendritic catalyst precursors: evaluation in Heck reactions [J].
Smith, GS ;
Mapolie, SF .
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 2004, 213 (02) :187-192
[67]   Arene ruthenium complexes as anticancer agents [J].
Suess-Fink, Georg .
DALTON TRANSACTIONS, 2010, 39 (07) :1673-1688
[68]   Arene ruthenium oxinato complexes: Synthesis, molecular structure and catalytic activity for the hydrogenation of carbon dioxide in aqueous solution [J].
Thai, Trieu-Tien ;
Therrien, Bruno ;
Suess-Fink, Georg .
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2009, 694 (25) :3973-3981
[69]   The "Complex-in-a-Complex" cations [(acac)2M⊂RU6(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+:: A Trojan horse for cancer cells [J].
Therrien, Bruno ;
Suess-Fink, Georg ;
Govindaswamy, Padavattan ;
Renfrew, Anna K. ;
Dyson, Paul J. .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (20) :3773-3776
[70]   Mono and dinuclear arene ruthenium complexes containing 6,7-dimethyl-2,3-di(pyridine-2-yl)quinoxaline as chelating ligand:: Synthesis and molecular structure [J].
Therrien, Bruno ;
Suess-Fink, Georg ;
Govindaswamy, Padavattan ;
Said-Mohamed, Cynthia .
POLYHEDRON, 2007, 26 (15) :4065-4072
12345678