Process for developing 3β-[4-(S)-arylacetylamino-4β-(2-(2-furyl)ethyl]azetidin-2-one:: A carbacephem key intermediate

被引：4
|
作者：
Kumar, Y [1 ]
Tewari, N [1 ]
Nizar, H [1 ]
Rai, BP [1 ]
Singh, SK [1 ]
机构：
[1] Ranbaxy Res Labs, Div Chem Res, Gurgaon 122001, Haryana, India
来源：
ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2003年 / 7卷 / 06期
关键词：
D O I：
10.1021/op034074h
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
An optimized process for the stereospecific synthesis of carbacephem key intermediates 3beta-[4-(S)-phenoxyacetylamino-4beta-[2(2-furyl)ethyl]azetidin-2-one (1) and 3beta-[4-(S)-phenyl-acetylamino-4beta-[2(2-furyl)ethyl)]azetidin-2-one] (2) is described. This report provides an efficient and cost-effective process for achieving a consistent yield and quality of intermediates 1 and 2 via Birch reduction employing a sodium/ammonia instead of lithium/ammonia system.
引用
收藏
页码：933 / 935
页数：3
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