Advances in mast cell biology

被引：10
|
作者：
Boyce, Joshua A. [1 ]
机构：
[1] Brigham & Womens Hosp, Dept Med, Div Allergy & Clin Immunol, Hale Bldg Transformat Med,Rm 5002V,60 Fenwood Rd, Boston, MA 02115 USA
来源：
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2022年 / 149卷 / 06期
关键词：
Mast cells; systemic mastocytosis; AERD; CRSwNP; Staphyloccocus; single cell genomics; Mas-related G-protein-coupled receptor 2; CHRONIC RHINOSINUSITIS; NASAL POLYPS; INFLAMMATION; MIDOSTAURIN; ACTIVATION; INHIBITORS; RESPONSES; BACTERIAL;
D O I：
10.1016/j.jaci.2022.03.029
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Mast cells (MCs) contribute prominently to all allergic diseases, yet are still poorly understood owing to their exclusive residence in tissues. Recently, the use of RNA-sequencing, proteomics, and other technological advances have accelerated the acquisition of new knowledge. This includes an expanded definition of MC heterogeneity and developmental origins, previously unrecognized functions for MCs, discoveries of genetic causes of MC-related disorders, the introduction of new therapies for clonal MC disease, and the identification of new potential target for treatments. This issue of Advances addresses key studies from 2020 to 2021.
引用
收藏
页码：1919 / 1925
页数：7
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