Flavonoids and genomic instability induced by ionizing radiation

被引：63

作者：

Hosseinimehr, Seyed Jalal ^{[1
,2
]}

机构：

[1] Mazandaran Univ Med Sci, Fac Pharm, Dept Radiopharm, Tradit & Complementary Med Res Ctr, Sari 48175861, Iran

[2] Uppsala Univ, Rudbeck Lab, Unit Biomed Radiat Sci, S-75185 Uppsala, Sweden

来源：

DRUG DISCOVERY TODAY | 2010年 / 15卷 / 21-22期

关键词：

QUERCETIN-DNA INTERACTIONS; DOUBLE-STRAND BREAKS; AMINO-ACID-RESIDUES; MICE BONE-MARROW; GAMMA-IRRADIATION; IN-VIVO; SUPEROXIDE-DISMUTASE; ANTIOXIDANT ACTIVITY; RADICAL SCAVENGERS; OXIDATIVE DAMAGE;

D O I：

10.1016/j.drudis.2010.09.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

DNA is the cellular target that has the most damage induced by ionizing radiation (IR). If genomic instability resulting from this DNA damage is not correctly repaired, it leads to mutation, cancer and cell death. Flavonoids are a family of natural products that affect oxidative stress and enhance genomic stability through DNA interaction. Although flavonoids exert protective effects against IR in normal cells, they enhance genotoxicity effects of this radiation in cancer cells, a beneficial effect that is of interest in the design of new anticancer pharmaceuticals. This review describes the molecular effects of IR on DNA structure and mechanisms by which flavonoids exert their effect on ionizing-radiation-induced genomic instability.

引用

页码：907 / 918

页数：12

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