ATP7B expression is associated with in vitro sensitivity to cisplatin in non-small cell lung cancer

被引：20

作者：

Inoue, Yoshimasa ^{[1
]}

Matsumoto, Hozumi ^{[2
]}

Yamada, Shunsuke ^{[1
]}

Kawai, Kenji ^{[2
]}

Suemizu, Hiroshi ^{[2
]}

Gika, Masatoshi ^{[3
]}

Takanami, Iwao ^{[4
]}

Nakamura, Masato ^{[5
]}

Iwazaki, Masayuki ^{[6
]}

机构：

[1] Tokai Univ, Dept Gen Thorac Surg, Hachioji Hosp, Tokyo 1920032, Japan

[2] Cent Inst Expt Anim, Kanagawa 2160003, Japan

[3] Saitama Med Ctr, Dept Gen Thorac Surg, Saitama 3508550, Japan

[4] Teikyo Univ, Dept Surg, Sch Med, Tokyo 1738605, Japan

[5] Tokai Univ, Sch Med, Dept Gen Thorac Surg, Kanagawa 2591193, Japan

[6] Tokai Univ, Sch Med, Dept Pathol, Kanagawa 2591193, Japan

来源：

ONCOLOGY LETTERS | 2010年 / 1卷 / 02期

关键词：

non-small cell lung cancer; chemosensitivity copper-transporting; P-type adenosine triphosphatase; cisplatin collagen; gel-droplet embedded culture drug sensitivity test; ADENOSINE-TRIPHOSPHATASE ATP7B; COPPER TRANSPORTING ATPASE; DROPLET EMBEDDED CULTURE; OVARIAN-CARCINOMA CELLS; WILSON-DISEASE GENE; CHEMORESISTANCE MARKER; RESISTANCE; CHEMOSENSITIVITY; XENOGRAFTS; CHEMOTHERAPY;

D O I：

10.3892/ol_00000049

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Copper-transporting P-type adenosine triphosphatase (ATP7B) is reportedly associated with platinum drug resistance in various solid tumors However, the impact of ATP7B on platinum drug resistance in non-small cell lung cancer (NSCLC) remains unclear We investigated in vitro cisplatin (CDDP) sensitivity using the collagen gel-droplet embedded culture drug sensitivity test The ATP7B mRNA expression level in each specimen was also examined using real-time polymerase chain reaction The relationship between ATP7B expression and in vitro CDDP sensitivity was then evaluated The ATP7B mRNA expression levels in CDDP-resistant tumors were significantly higher than those in the CDDP-sensitive group (p=0 015, Mann-Whitney U test) Our results suggested that ATP7B expression is a promising chemoresistance marker for cisplatin

引用

页码：279 / 282

页数：4

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