Synthesis of New Derivatives of 3-Aryl-1,5-dimethyl-1H-[1,2,4]triazolo[4′,3′:1,2]pyrimido[4,5-e][1,3,4]oxadiazines as Potential Antiproliferative Agents

被引：17

作者：

Bakavoli, Mehdi ^{[1
]}

Rahimizadeh, Mohammad ^{[1
]}

Shiri, Ali ^{[1
]}

Akbarzadeh, Marzieh ^{[1
]}

Mousavi, Seyed-Hadi ^{[2
,3
,4
]}

Tayarani-Najaran, Zahra ^{[2
,3
]}

Atapour-Mashhad, Hoda ^{[4
,5
]}

Nikpour, Mohsen ^{[6
]}

机构：

[1] Ferdowsi Univ Mashhad, Sch Sci, Dept Chem, Mashhad 917751436, Iran

[2] Mashhad Univ Med Sci, Sch Med, Dept Pharmacol, Mashhad, Iran

[3] Mashhad Univ Med Sci, Sch Med, Pharmacol Res Ctr Med Plants, Mashhad, Iran

[4] Mashhad Univ Med Sci, Med Toxicol Res Ctr, Mashhad, Iran

[5] PNU, Dept Chem, Mashhad, Iran

[6] Islamic Azad Univ, Ahvaz Branch, Sch Sci, Dept Chem, Ahvaz, Iran

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2011年 / 48卷 / 01期

关键词：

HETEROCYCLIC-COMPOUNDS; FACILE SYNTHESIS; ANTIBACTERIAL; HYDRAZONES;

D O I：

10.1002/jhet.509

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from pyrimido[4,5-e][1,3,4]oxadiazines (3a-c), a synthetic pathway to [1,2,4]triazolo[4',3':1,2]pyrimido[4,5-e][1,3,4]oxadiazines (5a-i) is described. The reaction of pyrimido[4,5-e][1,3,4]oxadiazines (3a-c) with hydrazine hydrate afforded the corresponding hydrazino derivatives (4a-c). Further treatment of these compounds with different orthoesters in acetic acid gave the corresponding [1,2,4]triazolo[4',3':1,2]pyrimido[4,5-e][1,3,4]oxadiazines (5a-i). Compound (3a) and (5b), as examples, were tested on different cancer cell lines including He La, MCF-7, and HepG2. Malignant cells were cultured in DMEM medium and incubated with different concentrations of the titled compounds. Cell viability was quantitated by MTT assay.

引用

页码：183 / 187

页数：5

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