SOX2 functions in adult neural stem cells

被引：202
作者：
Episkopou, V [1 ]
机构：
[1] Imperial Coll Sch Med, MRC, Ctr Clin Sci, London W12 0NN, England
来源：
TRENDS IN NEUROSCIENCES | 2005年 / 28卷 / 05期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/j.tins.2005.03.003
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Sox2 is expressed highly in the neuroepithelium of the developing CNS and has been shown to function in neural stem cells. Because Sox2-null mutant mice fail to develop beyond implantation, the role of SOX2 in the CNS has lacked validation. A new genetic model addresses the role of SOX2 in the adult brain and provides evidence that it is involved in the maintenance of neurons in specific regions, in the proliferation and/or maintenance of neural stem cells, and in neurogenesis.
引用
收藏
页码：219 / 221
页数：3
相关论文
共 19 条
  • [1] Neurogenesis in adult subventricular zone
    Alvarez-Buylla, A
    García-Verdugo, JM
    [J]. JOURNAL OF NEUROSCIENCE, 2002, 22 (03) : 629 - 634
  • [2] Multipotent cell lineages in early mouse development depend on SOX2 function
    Avilion, AA
    Nicolis, SK
    Pevny, LH
    Perez, L
    Vivian, N
    Lovell-Badge, R
    [J]. GENES & DEVELOPMENT, 2003, 17 (01) : 126 - 140
  • [3] Proneural genes and the specification of neural cell types
    Bertrand, N
    Castro, DS
    Guillemot, F
    [J]. NATURE REVIEWS NEUROSCIENCE, 2002, 3 (07) : 517 - 530
  • [4] Vertebrate neurogenesis is counteracted by Sox1-3 activity
    Bylund, M
    Andersson, E
    Novitch, BG
    Muhr, J
    [J]. NATURE NEUROSCIENCE, 2003, 6 (11) : 1162 - 1168
  • [5] Mutations in SOX2 cause anophthalmia
    Fantes, J
    Ragge, NK
    Lynch, SA
    McGill, NI
    Collin, JRO
    Howard-Peebles, PN
    Hayward, C
    Vivian, AJ
    Williamson, K
    van Heyningen, V
    FitzPatrick, DR
    [J]. NATURE GENETICS, 2003, 33 (04) : 461 - 463
  • [6] Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain
    Ferri, ALM
    Cavallaro, M
    Braida, D
    Di Cristofano, A
    Canta, A
    Vezzani, A
    Ottolenghi, S
    Pandolfi, PP
    Sala, M
    DeBiasi, S
    Nicolis, SK
    [J]. DEVELOPMENT, 2004, 131 (15): : 3805 - 3819
  • [7] CAMPOMELIC DYSPLASIA AND AUTOSOMAL SEX REVERSAL CAUSED BY MUTATIONS IN AN SRY-RELATED GENE
    FOSTER, JW
    DOMINGUEZSTEGLICH, MA
    GUIOLI, S
    KWOK, C
    WELLER, PA
    STEVANOVIC, M
    WEISSENBACH, J
    MANSOUR, S
    YOUNG, ID
    GOODFELLOW, PN
    BROOK, JD
    SCHAFER, AJ
    [J]. NATURE, 1994, 372 (6506) : 525 - 530
  • [8] SOX2 functions to maintain neural progenitor identity
    Graham, V
    Khudyakov, J
    Ellis, P
    Pevny, L
    [J]. NEURON, 2003, 39 (05) : 749 - 765
  • [9] A GENE-MAPPING TO THE SEX-DETERMINING REGION OF THE MOUSE Y-CHROMOSOME IS A MEMBER OF A NOVEL FAMILY OF EMBRYONICALLY EXPRESSED GENES
    GUBBAY, J
    COLLIGNON, J
    KOOPMAN, P
    CAPEL, B
    ECONOMOU, A
    MUNSTERBERG, A
    VIVIAN, N
    GOODFELLOW, P
    LOVELLBADGE, R
    [J]. NATURE, 1990, 346 (6281) : 245 - 250
  • [10] Kamachi Y, 1999, MOL CELL BIOL, V19, P107
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