Novel Contrast-Enhanced Ultrasound Evaluation in Neonatal Hypoxic Ischemic Injury: Clinical Application and Future Directions

被引：37
|
作者：
Hwang, Misun [1 ]
De Jong, Robert M., Jr. [1 ]
Herman, Stephan [1 ]
Boss, Renee [2 ]
Riggs, Becky [3 ]
Tekes-Brady, Aylin [1 ]
Spevak, Melissa [1 ]
Poretti, Andrea [1 ]
Soares, Bruno P. [1 ]
Bailey, Christopher R. [1 ]
Dunn, Emily [1 ]
Shin, Samuel S. [4 ]
Shrot, Shai [1 ]
Huisman, Thierry A. G. M. [1 ]
机构：
[1] Johns Hopkins Univ Hosp, Div Pediat Radiol, Russell H Morgan Dept ment Radiol & Radiol Sci, Baltimore, MD 21287 USA
[2] Johns Hopkins Univ Hosp, Dept Pediat, Baltimore, MD 21287 USA
[3] Johns Hopkins Univ Hosp, Div Pediat Anesthesiol & Crit Care Med, Baltimore, MD 21287 USA
[4] Johns Hopkins Univ Hosp, Div Neurol & Neurol Surg, Baltimore, MD USA
来源：
JOURNAL OF ULTRASOUND IN MEDICINE | 2017年 / 36卷 / 11期
关键词：
contrast-enhanced ultrasound; hypoxic ischemic injury; microbubbles; neonates; neuroimaging; pediatric ultrasound; CEREBRAL-BLOOD-FLOW; POSITRON-EMISSION-TOMOGRAPHY; CONGENITAL HEART-DEFECTS; MAGNETIC-RESONANCE; WHITE-MATTER; MEDIA REACTIONS; BRAIN-INJURY; PERFUSION; INFANTS; ENCEPHALOPATHY;
D O I：
10.1002/jum.14289
中图分类号：
O42 [声学];
学科分类号：
070206 ; 082403 ;
摘要：
Sensitive, specific, and safe bedside evaluation of brain perfusion is key to the early diagnosis, treatment, and improved survival of neonates with hypoxic ischemic injury. Contrast-enhanced ultrasound (US) imaging is a novel imaging technique in which intravenously injected gas-filled microbubbles generate enhanced US echoes from an acoustic impedance mismatch. This article describes contrast-enhanced US imaging in 2 neonates with hypoxic ischemic injury and future directions on developing quantitative contrast-enhanced US techniques for improved characterization of perfusion abnormalities. The importance of studying the temporal evolution of brain perfusion in neonatal hypoxic ischemic injury is also highlighted.
引用
收藏
页码：2379 / 2386
页数：8
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